{"id":"W2412751116","doi":"10.18632/oncotarget.9654","title":"Targeting hypoxic microenvironment of pancreatic xenografts with the hypoxia-activated prodrug TH-302","year":2016,"lang":"en","type":"article","venue":"Oncotarget","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Domtar (Canada); University Health Network; University of Toronto; Ontario Institute for Cancer Research","funders":"","keywords":"Hypoxia (environmental); Prodrug; Medicine; Cancer research; Pharmacology; Chemistry; Oxygen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001236254,0.0001752245,0.0001707677,0.00008485068,0.0001016029,0.0001731922,0.00009969826,0.0001637366,0.001189467],"category_scores_gemma":[0.00006535648,0.00009328602,0.0001205649,0.00008845234,0.0001006188,0.0001378601,0.0001007742,0.0004541544,0.0003500107],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001625393,"about_ca_system_score_gemma":0.0002384012,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005854607,"about_ca_topic_score_gemma":0.000967443,"domain_scores_codex":[0.9999592,0.000004901468,0.000002861434,0.000007454228,0.00001686549,0.000008716903],"domain_scores_gemma":[0.999971,0.000005321358,0.000005787737,0.000003835229,0.000004307,0.000009679251],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002848195,0.00009054365,0.0002868982,0.00004496544,0.000004845739,0.0001054736,0.00001915613,0.0002904878,0.9954658,0.0001184029,0.0002999419,0.002988582],"study_design_scores_gemma":[0.00009427722,0.001438197,0.00227655,0.000007851772,0.00001958189,0.0006033857,0.00004048939,0.001805594,0.987968,0.00004946328,0.005692127,0.000004565351],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909621,0.002209594,0.002078227,0.0001966468,0.00007850136,0.00006833546,0.0002937846,0.00007889298,0.004033937],"genre_scores_gemma":[0.9917397,0.001606765,0.002019212,0.00008620549,0.00001629403,0.00004828404,0.0003931203,0.00002072397,0.004069507],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001189467,"threshold_uncertainty_score":0.003979146,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009117242703890445,"score_gpt":0.2115238428221598,"score_spread":0.2024066001182694,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}