{"id":"W2412882068","doi":"10.1038/srep27379","title":"Heterogeneous Nuclear Ribonucleoprotein L is required for the survival and functional integrity of murine hematopoietic stem cells","year":2016,"lang":"en","type":"article","venue":"Scientific Reports","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute for Research in Immunology and Cancer; McGill University; Université de Montréal; Montreal Clinical Research Institute","funders":"Canadian Institutes of Health Research","keywords":"Heterogeneous nuclear ribonucleoprotein; Biology; Haematopoiesis; Stem cell; Ribonucleoprotein; Cell biology; Programmed cell death; Propidium iodide; Molecular biology; RNA-binding protein; Cancer research; Apoptosis; RNA; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001225018,0.0003262569,0.0001750462,0.0002715258,0.0001335817,0.0002435464,0.0001916227,0.0002840528,0.0007315051],"category_scores_gemma":[0.000190949,0.000167041,0.0001395377,0.0001256713,0.0002706053,0.0001363683,0.0002129078,0.0002280387,0.0006021018],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002661328,"about_ca_system_score_gemma":0.0001926752,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003773033,"about_ca_topic_score_gemma":0.0005294805,"domain_scores_codex":[0.9998358,0.0000320885,0.00002017863,0.00003156127,0.00005191672,0.0000283257],"domain_scores_gemma":[0.9995354,0.00004719255,0.0002483485,0.000040726,0.00002923032,0.00009920321],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005968829,0.000007114954,0.0003101187,0.00001306335,0.000001929304,0.00007542521,0.00000558498,0.00003932946,0.9987199,0.00005483316,0.00001785776,0.0006952203],"study_design_scores_gemma":[0.00001390977,0.0002273549,0.009453951,0.000006534692,0.0000125737,0.0004958954,0.00001811067,0.0005719943,0.9872057,0.00007444673,0.001915697,0.000003828753],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924409,0.001381756,0.00443995,0.0001062775,0.00001183995,0.0000159929,0.0004332732,0.0001995093,0.0009705406],"genre_scores_gemma":[0.9954342,0.0004150724,0.002152037,0.00002856923,0.000007736786,0.00001445714,0.0007975298,0.00003461301,0.001115847],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007315051,"threshold_uncertainty_score":0.002447128,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02562322210113348,"score_gpt":0.2572430790987381,"score_spread":0.2316198569976046,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}