{"id":"W2412914653","doi":"10.1038/nature18288","title":"Dual targeting of p53 and c-MYC selectively eliminates leukaemic stem cells","year":2016,"lang":"en","type":"article","venue":"Nature","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":229,"is_retracted":false,"has_abstract":false,"ca_institutions":"Discovery Centre","funders":"Medical Research Council; Imperial Experimental Cancer Medicine Centre; Howat Foundation; Cancer Research UK; Constellation Pharmaceuticals","keywords":"Stem cell; Cancer research; Tyrosine kinase; Haematopoiesis; Imatinib mesylate; Biology; Imatinib; Bruton's tyrosine kinase; breakpoint cluster region; Myeloid leukemia; Cell biology; Signal transduction; Receptor; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001138634,0.0001428698,0.0002548957,0.00006705482,0.00003250355,0.000003978205,0.00004658447,0.0005781399,0.00006852869],"category_scores_gemma":[0.00005718867,0.00008718829,0.00004827557,0.0001153647,0.00006075611,0.00006128854,0.00004102125,0.0005670736,0.00001891042],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003419416,"about_ca_system_score_gemma":0.0001724771,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001287448,"about_ca_topic_score_gemma":0.000002535088,"domain_scores_codex":[0.9991248,0.0000265646,0.0001646501,0.0002543775,0.0002131342,0.0002164415],"domain_scores_gemma":[0.9993866,0.0001723191,0.00008800238,0.000151392,0.0001194648,0.00008223799],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002451855,0.00008769838,0.02431343,0.0001971485,0.000173754,0.00007584912,0.0004015675,4.317466e-7,0.9289166,0.0001489521,0.01412843,0.03131091],"study_design_scores_gemma":[0.004420636,0.0003493671,0.02339914,0.0003883032,0.0001386842,0.0001033687,0.0001462299,0.0000251815,0.9639847,0.00008667005,0.006807631,0.0001500467],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939402,0.004108885,0.000009013463,0.0006919532,0.0001226926,0.0002209769,0.00002751516,0.00004330663,0.0008354476],"genre_scores_gemma":[0.9962745,0.0002000258,0.0005728015,0.0001487835,0.0001532671,0.000005669132,0.000004728264,0.00002208623,0.002618125],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03506809,"threshold_uncertainty_score":0.4459144,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007148326169444772,"score_gpt":0.2449901059690739,"score_spread":0.2378417797996292,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}