{"id":"W2412948744","doi":"","title":"The antitumor ether lipid 1-Q-octadecyl-2-O-methyl-rac-glycerophosphocholine (ET-18-OCH3) inhibits the association between Ras and Raf-1.","year":2003,"lang":"en","type":"article","venue":"PubMed","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"","keywords":"Cytosol; GTP'; MAPK/ERK pathway; Kinase; Molecular biology; Biology; Chemistry; Biochemistry; Cell biology; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001885264,0.0001711131,0.0001488293,0.00002644763,0.0003424554,0.0001305979,0.0001523116,0.0001717121,0.00001288449],"category_scores_gemma":[0.001029387,0.0001094523,0.00008627436,0.00015728,0.00008992595,0.000009128843,0.00007831013,0.0001951791,0.000007188151],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003631516,"about_ca_system_score_gemma":0.00005094075,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001446467,"about_ca_topic_score_gemma":0.00002325171,"domain_scores_codex":[0.9984474,0.0003519751,0.0002626298,0.0003030539,0.0002440624,0.0003908986],"domain_scores_gemma":[0.999138,0.0001269734,0.0002023006,0.0003192299,0.0001093043,0.0001042022],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007731584,0.0003657048,0.1947623,0.0001336323,0.001935637,0.00001489137,0.0007765945,0.0003605195,0.381527,0.01674661,0.02659945,0.3760045],"study_design_scores_gemma":[0.001165145,0.00003391731,0.1234805,0.000008927777,0.00006366278,0.000008206046,0.00005266372,0.00001407366,0.4784127,0.0006406446,0.3958533,0.000266248],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9866465,0.004982498,0.0007515083,0.003024649,0.0002611856,0.0009809305,0.0000200061,0.0000287072,0.003304067],"genre_scores_gemma":[0.995063,0.0004782527,0.0001402073,0.0007652889,0.0003527876,0.0003169403,0.00003460654,0.00002777144,0.002821151],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3757383,"threshold_uncertainty_score":0.4463333,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01598750578090269,"score_gpt":0.237949171112894,"score_spread":0.2219616653319913,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}