{"id":"W2412986543","doi":"10.1038/nsmb.3234","title":"Heavy lessons in protein allostery","year":2016,"lang":"en","type":"article","venue":"Nature Structural & Molecular Biology","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"","keywords":"Allosteric regulation; Hydrogen–deuterium exchange; Chemistry; Posttranslational modification; Computational biology; Mass spectrometry; Covalent bond; Biochemistry; Biophysics; Enzyme; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002001202,0.0004332944,0.0007437958,0.000560706,0.001321543,0.001489694,0.001159981,0.001858195,0.007096063],"category_scores_gemma":[0.003868305,0.0002645267,0.0003642062,0.000417806,0.006450449,0.007422047,0.002283009,0.005932801,0.001821991],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001350462,"about_ca_system_score_gemma":0.0005900954,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005822007,"about_ca_topic_score_gemma":0.00053835,"domain_scores_codex":[0.9996158,0.00006088354,0.00001679906,0.0001011114,0.0001082445,0.00009719331],"domain_scores_gemma":[0.9982369,0.0006813231,0.0001065927,0.0004690219,0.0001955538,0.00031056],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005514258,0.0001068322,0.001516283,0.0003798002,0.00008046181,0.000658081,0.0007232749,0.003169432,0.02609616,0.7705147,0.03536563,0.1608378],"study_design_scores_gemma":[0.00006143996,0.000101262,0.00137548,0.00007074267,0.00001717746,0.0004191276,0.0003180326,0.001522042,0.005379089,0.8823712,0.1083353,0.000028946],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.24232,0.1585151,0.09541442,0.3453268,0.02117449,0.00005138668,0.0006318163,0.001624836,0.1349412],"genre_scores_gemma":[0.8809381,0.04243473,0.008129741,0.02493401,0.009444671,0.00005907855,0.0002661821,0.0003923052,0.0334012],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.007096063,"threshold_uncertainty_score":0.02373868,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006160910281703106,"score_gpt":0.3064472651267111,"score_spread":0.300286354845008,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}