{"id":"W2412986543","doi":"10.1038/nsmb.3234","title":"Heavy lessons in protein allostery","year":2016,"lang":"en","type":"article","venue":"Nature Structural & Molecular Biology","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"","keywords":"Allosteric regulation; Hydrogen–deuterium exchange; Chemistry; Posttranslational modification; Computational biology; Mass spectrometry; Covalent bond; Biochemistry; Biophysics; Enzyme; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000133293,0.0002873946,0.0002306493,0.00008109891,0.00004548905,0.00001281337,0.0004381003,0.0008350274,0.00005221443],"category_scores_gemma":[0.0003915485,0.000198141,0.000149428,0.0001387771,0.000204244,0.000004569147,0.0002210159,0.0003096458,0.00001360418],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003825558,"about_ca_system_score_gemma":0.0001032878,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008749845,"about_ca_topic_score_gemma":0.00002085094,"domain_scores_codex":[0.9982027,0.000217105,0.000263901,0.0007034368,0.0001187448,0.0004941151],"domain_scores_gemma":[0.9991186,0.00001469411,0.00009187314,0.0005683583,0.00008227017,0.0001241768],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001984411,0.00001512804,0.00192289,0.000008850412,0.00003763616,0.00004396618,0.000006482293,0.000003558859,0.9871491,0.006380457,0.0002037268,0.004029784],"study_design_scores_gemma":[0.00100663,0.0002539388,0.00234552,0.00004172987,0.000009587885,0.00004125767,0.000005473075,0.000002871986,0.982565,0.008780662,0.004606495,0.0003408053],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930446,0.002026221,0.001015262,0.002828493,0.0002886216,0.0003628976,0.0000913855,0.00003095531,0.0003115696],"genre_scores_gemma":[0.9973034,0.00001205141,0.0009442334,0.001125295,0.000194787,0.00005295454,0.0001335465,0.00003797403,0.0001957101],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004584051,"threshold_uncertainty_score":0.8079956,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006160910281703106,"score_gpt":0.3064472651267111,"score_spread":0.300286354845008,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}