{"id":"W2413133638","doi":"","title":"ML265: A potent PKM2 activator induces tetramerization and reduces tumor formation and size in a mouse xenograft model","year":2013,"lang":"en","type":"article","venue":"","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"","keywords":"PKM2; Activator (genetics); In vivo; Isozyme; Gene isoform; Dimer; Ex vivo; Pyruvate kinase; Chemistry; Enzyme; Biology; In vitro; Biochemistry; Cell biology; Cancer research; Molecular biology; Glycolysis; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002148361,0.0003913012,0.0002940247,0.0003646966,0.0001508376,0.0002206989,0.0002853078,0.0003140479,0.001556947],"category_scores_gemma":[0.00006984546,0.0001478915,0.0002072359,0.0001951085,0.0002378978,0.0001967189,0.0001402795,0.0009306414,0.0003909013],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002872277,"about_ca_system_score_gemma":0.0002673377,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005950771,"about_ca_topic_score_gemma":0.0009174114,"domain_scores_codex":[0.9998622,0.00002950258,0.000009277646,0.00002312551,0.00004438591,0.00003148754],"domain_scores_gemma":[0.9998838,0.0000158305,0.0000307366,0.00001034467,0.000008302858,0.00005097918],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003570924,0.000158105,0.00008067315,0.00002395407,0.000004747944,0.00002884998,0.00001351585,0.000118262,0.9980397,0.00006311639,0.00011663,0.0009954592],"study_design_scores_gemma":[0.00006589512,0.001697268,0.0008756889,0.000002930626,0.000009534765,0.000120036,0.00001427248,0.0006448518,0.9952212,0.00001924241,0.001325921,0.000003311113],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934442,0.0007084741,0.003048659,0.0002079111,0.00003313731,0.00006350254,0.0004560765,0.0003150974,0.001722854],"genre_scores_gemma":[0.992656,0.000581354,0.002296208,0.00007235298,0.00001811402,0.00005324107,0.000714161,0.00005345012,0.003555144],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001556947,"threshold_uncertainty_score":0.005208433,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008110037944726924,"score_gpt":0.2217424933364085,"score_spread":0.2136324553916815,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}