{"id":"W2413352928","doi":"10.1016/j.exphem.2016.06.002","title":"Overexpression of LMO2 causes aberrant human T-Cell development in vivo by three potentially distinct cellular mechanisms","year":2016,"lang":"en","type":"article","venue":"Experimental Hematology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Stichting Kinderen Kankervrij","keywords":"Progenitor cell; Biology; Haematopoiesis; CD8; Cell biology; T cell; Stem cell; CD34; Cancer research; Immunology; Molecular biology; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001848009,0.0002448563,0.000559875,0.0001601096,0.00007428526,0.000006150976,0.0001999458,0.0001761435,0.01021457],"category_scores_gemma":[0.00001293439,0.000174343,0.00009522864,0.0001022153,0.0001809458,0.00005841328,0.0002030257,0.0001320519,0.00005138302],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002169654,"about_ca_system_score_gemma":0.0001007737,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000142158,"about_ca_topic_score_gemma":0.00005827186,"domain_scores_codex":[0.9979957,0.00008208326,0.0005547507,0.0004400504,0.00045766,0.0004697347],"domain_scores_gemma":[0.9992129,0.00006782899,0.0001335392,0.0003846354,0.0000434781,0.000157573],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004175121,0.001048152,0.002220445,0.0000832661,0.0000363924,0.0001250961,0.000391025,5.939031e-8,0.9917259,0.002713894,0.0008952489,0.0003430744],"study_design_scores_gemma":[0.003856465,0.000472717,0.0002143612,0.000296115,0.000007313432,0.00007952534,0.0001981983,0.000004311579,0.9926901,0.0002637907,0.001725172,0.0001918552],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925451,0.001649937,0.001460496,0.00009893658,0.0001138332,0.0006079729,0.0000118221,0.00004095826,0.003470996],"genre_scores_gemma":[0.9944348,0.000008224282,0.00115151,0.00003920504,0.00002189576,0.00009001409,0.00001982228,0.0000469462,0.004187634],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01016318,"threshold_uncertainty_score":0.9906902,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02300132305908279,"score_gpt":0.3063083605959264,"score_spread":0.2833070375368436,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}