{"id":"W2413401407","doi":"10.1016/j.bmc.2016.05.052","title":"The action mechanism of daptomycin","year":2016,"lang":"nl","type":"review","venue":"Bioorganic & Medicinal Chemistry","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":302,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Waterloo","funders":"","keywords":"Daptomycin; Lipopeptide; Chemistry; Bacterial cell structure; Antibiotics; Mechanism of action; Peptidoglycan; Mode of action; Bacteria; Phosphatidylglycerol; Streptomyces; Microbiology; Biosynthesis; Biochemistry; Membrane; Cell wall; Biology; In vitro; Phospholipid; Staphylococcus aureus; Gene; Vancomycin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.001576324,0.0009636912,0.002301164,0.00007218329,0.000343748,0.00003412124,0.001003811,0.00123053,0.009365871],"category_scores_gemma":[0.002121536,0.0004656325,0.00073048,0.0005754921,0.0007075418,0.00006169247,0.0002719941,0.00132109,0.001311426],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005405633,"about_ca_system_score_gemma":0.001405081,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004003651,"about_ca_topic_score_gemma":0.000001303004,"domain_scores_codex":[0.9951553,0.0001809002,0.001728399,0.00102677,0.001042769,0.0008658556],"domain_scores_gemma":[0.9952492,0.0007512186,0.001614051,0.001514782,0.0004487183,0.0004220713],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001268899,0.00009050287,8.772358e-7,0.01739394,0.0005901804,0.0000321471,0.00001949133,4.84841e-10,0.6646742,0.00009840143,0.01670326,0.3002701],"study_design_scores_gemma":[0.000477755,0.0001023387,0.000002953035,0.0208408,0.001664245,0.0003804438,0.00015034,4.092951e-7,0.4182966,0.00004569864,0.5577118,0.0003265573],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0009291966,0.9887018,0.00002291278,0.003825445,0.002112404,0.0009668687,0.0001686576,0.000066023,0.003206648],"genre_scores_gemma":[0.02768014,0.9258249,0.00002456222,0.0001081376,0.005733756,0.00000537921,0.0000863403,0.0001117609,0.04042504],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.5410086,"threshold_uncertainty_score":0.9997795,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03376171882164158,"score_gpt":0.2972312530513385,"score_spread":0.2634695342296969,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}