{"id":"W2413497297","doi":"10.2119/molmed.2014.00049","title":"The JAK-STAT Pathway Is Critical in Ventilator-Induced Diaphragm Dysfunction","year":2014,"lang":"en","type":"article","venue":"Molecular Medicine","topic":"Respiratory Support and Mechanisms","field":"Medicine","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"Royal Victoria Hospital","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute on Aging; National Institutes of Health; U.S. Department of Veterans Affairs","keywords":"stat; JAK-STAT signaling pathway; Medicine; Molecular medicine; Internal medicine; Signal transduction; Biology; Cell biology; Receptor; Cell cycle; STAT3; Tyrosine kinase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001781153,0.0003126516,0.0002064581,0.0001957921,0.0002262102,0.0004312696,0.0001087714,0.0003071911,0.00192023],"category_scores_gemma":[0.0001402647,0.0001251818,0.0002294258,0.000137601,0.0003127082,0.0002224704,0.000221927,0.000670951,0.0004078374],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002249279,"about_ca_system_score_gemma":0.0003295465,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001460812,"about_ca_topic_score_gemma":0.0002590268,"domain_scores_codex":[0.9998906,0.00002844257,0.00001301573,0.00001167101,0.00002756052,0.0000287304],"domain_scores_gemma":[0.999915,0.00001732986,0.00002956292,0.000004247763,0.00000921535,0.00002468485],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002959013,0.0002969792,0.01119864,0.0007403661,0.00007050244,0.002124747,0.0001160267,0.000964355,0.9398672,0.003571009,0.001524436,0.03656678],"study_design_scores_gemma":[0.0005934632,0.003271844,0.2963909,0.0004254128,0.0003430845,0.01540052,0.0006855748,0.01575138,0.6065791,0.009403287,0.05109219,0.00006330112],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.910749,0.07018501,0.006805735,0.002524488,0.000363352,0.00008147411,0.0006715969,0.0002553537,0.008363892],"genre_scores_gemma":[0.9895075,0.007928751,0.0008214918,0.0001922985,0.00005998953,0.00001498187,0.0002209453,0.000005959922,0.00124813],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00192023,"threshold_uncertainty_score":0.006423771,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0157432042795672,"score_gpt":0.2866562921424338,"score_spread":0.2709130878628666,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}