{"id":"W2413592082","doi":"10.1111/apha.12726","title":"Is plasminogen activator inhibitor‐1 a physiological bottleneck bridging major depressive disorder and cardiovascular disease?","year":2016,"lang":"en","type":"review","venue":"Acta Physiologica","topic":"Cardiac Health and Mental Health","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; St. Joseph’s Healthcare Hamilton","funders":"Society for Women’s Health Research","keywords":"Major depressive disorder; Disease; Bioinformatics; Plasminogen activator inhibitor-1; Medicine; Depression (economics); Internal medicine; Pathological; Pathogenesis; Endocrinology; Psychology; Plasminogen activator; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002344503,0.0008910076,0.003864642,0.0001387397,0.0003428198,0.00002658918,0.0002329604,0.0006028321,0.000186394],"category_scores_gemma":[0.0002324521,0.0005069185,0.002073307,0.0002355696,0.0002563493,0.0001130603,0.0004490417,0.000717368,0.0001542805],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000235448,"about_ca_system_score_gemma":0.0006379646,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004927154,"about_ca_topic_score_gemma":2.317357e-7,"domain_scores_codex":[0.9957443,0.0004151302,0.0007405839,0.001561523,0.0005023088,0.001036192],"domain_scores_gemma":[0.9968231,0.0003167435,0.0003535827,0.001201998,0.00007004014,0.001234572],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003350708,0.0002784583,0.0001091024,0.02827988,0.001328395,0.0001283798,0.00002930344,1.2781e-7,0.0001907679,0.00000961046,0.009887063,0.9594238],"study_design_scores_gemma":[0.001440744,0.0003691763,0.004050676,0.01246234,0.002119717,0.0001074444,0.00001704183,0.000002508301,0.00001565445,0.00004846782,0.9787164,0.000649835],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01720859,0.9784608,0.000004872544,0.0002542013,0.0003187716,0.002650785,0.0007096591,0.0001451507,0.0002471672],"genre_scores_gemma":[0.03336571,0.9626698,0.00004500551,0.0009704346,0.001644621,0.0006620205,0.000391472,0.00009397879,0.0001569221],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9688293,"threshold_uncertainty_score":0.9997382,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04505345426897715,"score_gpt":0.3366324321498539,"score_spread":0.2915789778808767,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}