{"id":"W2413770936","doi":"10.1534/g3.116.028662","title":"<i>N</i>-Ethyl-<i>N</i>-Nitrosourea (ENU) Mutagenesis Reveals an Intronic Residue Critical for<i>Caenorhabditis elegans</i>3′ Splice Site Function<i>in Vivo</i>","year":2016,"lang":"en","type":"article","venue":"G3 Genes Genomes Genetics","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"University of Michigan; National Institute of General Medical Sciences; American Heart Association; National Institute on Aging; National Institutes of Health; American Cancer Society","keywords":"Caenorhabditis elegans; Intron; Biology; RNA splicing; Genetics; Histone octamer; Splice site mutation; Transversion; Alternative splicing; Conserved sequence; Gene; Sequence motif; Molecular biology; Exon; RNA; Histone; Peptide sequence; Nucleosome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007851238,0.0005606507,0.0005229093,0.0002738769,0.0003162772,0.0001004689,0.0007089981,0.000465139,0.0002583403],"category_scores_gemma":[0.00008758021,0.0004935548,0.0002846397,0.0004426352,0.0003055934,0.00003318607,0.0002422774,0.0001789121,0.00008056812],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008780123,"about_ca_system_score_gemma":0.000258214,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009489242,"about_ca_topic_score_gemma":0.001115245,"domain_scores_codex":[0.9956445,0.000304566,0.0007626789,0.001301279,0.0004736931,0.001513253],"domain_scores_gemma":[0.997355,0.0001875527,0.000134287,0.001348915,0.0004066941,0.0005675466],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003953157,0.0001097308,0.0116453,0.00007360469,0.00006514329,0.00001772844,0.00003483431,0.0001688193,0.785309,0.00007170362,0.003197916,0.198911],"study_design_scores_gemma":[0.002607411,0.002023393,0.003817534,0.00006434926,0.0001147559,0.00007554936,0.0001226462,0.0001968897,0.4681742,0.0008151124,0.5209048,0.001083433],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8507658,0.1348677,0.01127127,0.0007191751,0.000349696,0.0009186234,0.0006707068,0.00006057432,0.0003764647],"genre_scores_gemma":[0.8154674,0.1606498,0.007580924,0.001818823,0.002726225,0.0005381368,0.0002887397,0.0002915305,0.01063842],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5177069,"threshold_uncertainty_score":0.9997516,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01182954901005023,"score_gpt":0.2748090894442939,"score_spread":0.2629795404342437,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}