{"id":"W2413810829","doi":"10.1515/hsz-2015-0246","title":"Safety and pharmacokinetics of a kinin B1 receptor peptide agonist produced with different counter-ions","year":2015,"lang":"en","type":"article","venue":"Biological Chemistry","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Canadian Institutes of Health Research","keywords":"Pharmacokinetics; Kinin; Agonist; Pharmacology; Tolerability; Chemistry; Toxicity; Peptide; Receptor; Bradykinin; Internal medicine; Medicine; Endocrinology; Adverse effect; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001070971,0.0001770995,0.0003435567,0.0000111737,0.00004062806,0.00000976445,0.00007178947,0.0001156264,0.0001858858],"category_scores_gemma":[0.0001531253,0.0001081592,0.00005274211,0.00008046979,0.0002631773,0.00001752241,0.00005527743,0.0001259404,0.000003058018],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004148153,"about_ca_system_score_gemma":0.00006769363,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000105531,"about_ca_topic_score_gemma":8.999617e-7,"domain_scores_codex":[0.9990577,0.00001835961,0.0002698668,0.0002963426,0.0001673929,0.0001902996],"domain_scores_gemma":[0.9992695,0.00005792276,0.0001119709,0.0001890224,0.0001296353,0.0002419828],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002291508,0.0005181991,0.332943,0.0002249789,0.0001218518,0.0000157523,0.0002640699,0.000003076932,0.6588758,0.00006456731,0.002640245,0.002037012],"study_design_scores_gemma":[0.005128835,0.0009042473,0.1697584,0.0002564847,0.0001568912,0.0001235266,0.0003373899,0.00013269,0.7850084,0.00006111864,0.03775005,0.0003820245],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960241,0.0007882685,0.00003877862,0.0007622149,0.00004698647,0.0001898277,0.00005135128,0.00005809018,0.002040409],"genre_scores_gemma":[0.997663,0.0001720267,0.0002767065,0.0001184068,0.0002399588,0.00001185096,0.0001853,0.00001144916,0.001321334],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1631846,"threshold_uncertainty_score":0.4410603,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03963329398160325,"score_gpt":0.2746107908450026,"score_spread":0.2349774968633993,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}