{"id":"W2413861093","doi":"","title":"Overcoming cisplatin resistance: design of novel hydrophobic platinum compounds.","year":2000,"lang":"en","type":"article","venue":"PubMed","topic":"Chemotherapy-induced organ toxicity mitigation","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; WiLAN (Canada); Alberta Children's Hospital","funders":"","keywords":"Cisplatin; Cytotoxicity; Platinum; Chemistry; Hydrophobic effect; DNA damage; Stereochemistry; Biochemistry; Combinatorial chemistry; DNA; In vitro; Biology; Chemotherapy; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001072017,0.000381451,0.0004397547,0.0001833117,0.0001371684,0.0002782004,0.0004204495,0.0003570678,0.001662592],"category_scores_gemma":[0.0002144004,0.0001762401,0.0001605565,0.0001577117,0.0001888913,0.000445505,0.0002534326,0.0004052866,0.0005485135],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003039994,"about_ca_system_score_gemma":0.0002028138,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002082291,"about_ca_topic_score_gemma":0.0004893708,"domain_scores_codex":[0.9999396,0.00001080192,0.000007335927,0.00001849592,0.00001326431,0.00001051301],"domain_scores_gemma":[0.9999194,0.0000099089,0.00002618345,0.000006711229,0.0000141522,0.00002355662],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00056355,0.0002236646,0.0004463549,0.0007145012,0.00003761254,0.0004102345,0.00004301989,0.002434913,0.9536739,0.001476558,0.0005898947,0.03938586],"study_design_scores_gemma":[0.0008189104,0.006184981,0.002055265,0.00007878693,0.0001675641,0.002007617,0.00004641621,0.004829073,0.9390526,0.000673182,0.04405262,0.0000330007],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9265559,0.02218883,0.03590999,0.0007857088,0.0002203471,0.001199239,0.0008549359,0.0003284239,0.01195657],"genre_scores_gemma":[0.9553252,0.01027679,0.02929369,0.0002781269,0.00004810607,0.0003497714,0.0006795434,0.00003973589,0.003709116],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001662592,"threshold_uncertainty_score":0.005561888,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03676736757213724,"score_gpt":0.2424338262893652,"score_spread":0.2056664587172279,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}