{"id":"W2413892817","doi":"10.1021/jacs.5b02810","title":"Enantioselective Rhodium-Catalyzed Allylic Substitution with a Nitrile Anion: Construction of Acyclic Quaternary Carbon Stereogenic Centers","year":2015,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Asymmetric Synthesis and Catalysis","field":"Chemistry","cited_by":119,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Stereocenter; Enantioselective synthesis; Chemistry; Nitrile; Rhodium; Allylic rearrangement; Alkylation; Tsuji–Trost reaction; Catalysis; Organic chemistry; Combinatorial chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003503209,0.0004889588,0.0002471742,0.0001715545,0.0001574523,0.0002361196,0.0005927416,0.0002952745,0.001124988],"category_scores_gemma":[0.0001712461,0.0001569066,0.0001844826,0.0001372062,0.0002475567,0.0003026795,0.0004576375,0.0006023791,0.0007833156],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002894138,"about_ca_system_score_gemma":0.0004284757,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006194335,"about_ca_topic_score_gemma":0.001270618,"domain_scores_codex":[0.9998442,0.00002689479,0.00001463963,0.00003337115,0.0000383391,0.00004248514],"domain_scores_gemma":[0.9999255,0.000008301392,0.00002149985,0.00001498607,0.00001227941,0.00001745619],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000967209,0.00005320616,0.0001827007,0.0001209234,0.000009766274,0.0003766549,0.00006926293,0.0004863708,0.9848372,0.004059241,0.0003410366,0.009366964],"study_design_scores_gemma":[0.00002692717,0.0001995362,0.0002916238,0.000007144713,0.00001210651,0.0004907535,0.00001733471,0.0008813709,0.9884368,0.0002185074,0.009400589,0.00001730199],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8681339,0.002571477,0.09325497,0.0004322628,0.0002407581,0.0002819691,0.0007451914,0.0005975559,0.03374194],"genre_scores_gemma":[0.9674622,0.001676258,0.02327804,0.00007401175,0.00002536562,0.00006144767,0.0002961608,0.00006519598,0.007061256],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001124988,"threshold_uncertainty_score":0.003763437,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01154446868766722,"score_gpt":0.2255233898988321,"score_spread":0.2139789212111649,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}