{"id":"W2413900656","doi":"10.1080/21541248.2016.1197873","title":"Every day I'm rufflin': Calcium sensing and actin dynamics in the growth factor-independent membrane ruffling of professional phagocytes","year":2016,"lang":"en","type":"review","venue":"Small GTPases","topic":"Phagocytosis and Immune Regulation","field":"Immunology and Microbiology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"Hospital for Sick Children; Cystic Fibrosis Canada","keywords":"Membrane ruffling; Cell biology; Pinocytosis; Biology; Guanine nucleotide exchange factor; RAC1; Phosphatidic acid; Phagocyte; GTPase; Actin cytoskeleton; Actin; Rac GTP-Binding Proteins; Phagocytosis; Membrane; Cytoskeleton; Endocytosis; Biochemistry; Signal transduction; Cell; Phospholipid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007388306,0.000498527,0.00142896,0.0003010418,0.0001787088,0.00002727087,0.0003712618,0.0006919057,0.00007352253],"category_scores_gemma":[0.0002641518,0.0002831682,0.0003315814,0.0001962052,0.000235969,0.0001243338,0.000207237,0.0006587247,0.00002722941],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000191718,"about_ca_system_score_gemma":0.0002811011,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002064781,"about_ca_topic_score_gemma":0.0001290381,"domain_scores_codex":[0.9969154,0.001139394,0.0009213499,0.0004817168,0.0001033087,0.000438833],"domain_scores_gemma":[0.9970388,0.00172864,0.0007171034,0.0004009881,0.00009180584,0.00002271106],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008915552,0.0002900917,0.0003718523,0.006217234,0.0005507211,0.0000196366,0.0004851558,3.476245e-7,0.006661312,0.001032349,0.0000778776,0.9842043],"study_design_scores_gemma":[0.007601462,0.0007999302,0.00886945,0.1264307,0.003409584,0.002072458,0.002992706,0.0001005696,0.05155712,0.0007754138,0.7908472,0.004543457],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01674434,0.980944,0.00009311058,0.0000689087,0.0009372648,0.000767667,0.000250951,0.00002947554,0.0001642235],"genre_scores_gemma":[0.111403,0.8873022,0.00002978227,0.00002837965,0.00009211357,0.0000261178,0.0004625068,0.00004839662,0.0006075057],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9796608,"threshold_uncertainty_score":0.999962,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05135183687768798,"score_gpt":0.3084828839893155,"score_spread":0.2571310471116275,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}