{"id":"W2413993846","doi":"10.3390/cells5020026","title":"Structural Mechanisms and Drug Discovery Prospects of Rho GTPases","year":2016,"lang":"en","type":"review","venue":"Cells","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Biotechnology and Biological Sciences Research Council; Wellcome Trust","keywords":"Druggability; GTPase; CDC42; RHOA; Ras superfamily; RAC1; Drug discovery; Biology; Prenylation; Drug development; Computational biology; Cell biology; Drug; Signal transduction; Bioinformatics; Biochemistry; Enzyme; Pharmacology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006398985,0.0008158712,0.001337581,0.002274584,0.0002954747,0.0009558881,0.001052167,0.001032728,0.003472702],"category_scores_gemma":[0.0006568622,0.0004163983,0.0006084748,0.001812635,0.0005482488,0.001457462,0.0008649135,0.00195986,0.00241355],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006946907,"about_ca_system_score_gemma":0.0007595291,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008343721,"about_ca_topic_score_gemma":0.001459773,"domain_scores_codex":[0.99978,0.00003865243,0.00002337566,0.00003762743,0.00008812985,0.00003233784],"domain_scores_gemma":[0.9998202,0.00006907852,0.00002473053,0.00001026967,0.00005451148,0.00002131555],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001236965,0.0001229442,0.000164447,0.01592361,0.0001277241,0.0004249693,0.0001040409,0.00132346,0.004872868,0.01739527,0.03827146,0.9211456],"study_design_scores_gemma":[0.00002176358,0.00008539246,0.0003274851,0.001084886,0.00004857731,0.0006845497,0.00002801429,0.0001432211,0.0006635921,0.003321886,0.9935759,0.00001477768],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002395953,0.9972933,0.0001984296,0.0002912549,0.0001631243,0.000006693654,0.00002516025,0.00001024898,0.001772218],"genre_scores_gemma":[0.001224944,0.9970587,0.0002413956,0.0002119998,0.0001114333,0.000008825739,0.00004472648,0.000002198118,0.001095781],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003472702,"threshold_uncertainty_score":0.01161736,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01324119307527022,"score_gpt":0.2620691507303238,"score_spread":0.2488279576550536,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}