{"id":"W2414003583","doi":"10.1021/acs.orglett.5b01719","title":"Modular Synthesis of Pyrazolones Using an Alkene Aminocarbonylation Reaction","year":2015,"lang":"en","type":"article","venue":"Organic Letters","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada; University of Ottawa","keywords":"Chemistry; Aromatization; Enol; Pyrazolones; Alkene; Nucleophile; Cascade reaction; Organic chemistry; Combinatorial chemistry; Medicinal chemistry; Catalysis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001650889,0.0004958702,0.0002174801,0.0001814603,0.0001397055,0.0002679558,0.0002679499,0.0002703054,0.001334423],"category_scores_gemma":[0.0001433618,0.0001718949,0.0002093087,0.0001620589,0.0001962949,0.0003102151,0.0003230411,0.0004760367,0.0007709137],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002754721,"about_ca_system_score_gemma":0.0002688817,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004074443,"about_ca_topic_score_gemma":0.0007886348,"domain_scores_codex":[0.9999009,0.000009478998,0.00001085686,0.00002698593,0.00001987119,0.00003183876],"domain_scores_gemma":[0.9999166,0.00001033092,0.00002206087,0.00001348753,0.00001706362,0.00002054568],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007200395,0.00002261867,0.0001190588,0.0000923106,0.000008516237,0.0002351699,0.00004415472,0.0003845567,0.9916697,0.0008215645,0.00008055467,0.006449825],"study_design_scores_gemma":[0.00002551667,0.0002801233,0.0005556466,0.000005909411,0.00001247783,0.0001905629,0.00001089656,0.0005310182,0.9920316,0.0001179997,0.006225387,0.00001292288],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9310493,0.002839797,0.05069505,0.000260126,0.0001951076,0.0003088863,0.0007279963,0.0006255417,0.01329809],"genre_scores_gemma":[0.9705374,0.001592907,0.02090169,0.00006477878,0.00001550934,0.0001067377,0.000330642,0.000035079,0.006415144],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001334423,"threshold_uncertainty_score":0.00446409,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01853775799833127,"score_gpt":0.2322506131230001,"score_spread":0.2137128551246689,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}