{"id":"W2414176242","doi":"10.1016/j.chest.2016.05.024","title":"Riociguat: Mode of Action and Clinical Development in Pulmonary Hypertension","year":2016,"lang":"en","type":"review","venue":"CHEST Journal","topic":"Pulmonary Hypertension Research and Treatments","field":"Medicine","cited_by":100,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Jewish General Hospital","funders":"National Institutes of Health; Bayer HealthCare; Pfizer; Ikaria; National Heart, Lung, and Blood Institute; Gilead Sciences; United Therapeutics Corporation","keywords":"Riociguat; Pulmonary hypertension; Chronic thromboembolic pulmonary hypertension; Medicine; Cardiology; Internal medicine; Intensive care medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005303327,0.0002696701,0.001632943,0.0003920705,0.00007042134,0.00001129614,0.00009642851,0.0003437112,0.00005578063],"category_scores_gemma":[0.0002567573,0.0001503981,0.0003191419,0.0001459303,0.0001057248,0.00008997181,0.00008642943,0.0008150875,0.00004841382],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002085186,"about_ca_system_score_gemma":0.001120795,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005339934,"about_ca_topic_score_gemma":0.000002170357,"domain_scores_codex":[0.9977263,0.000195732,0.001063646,0.0003022081,0.0004088673,0.0003032933],"domain_scores_gemma":[0.9986016,0.0002430494,0.0003741018,0.0002103164,0.0001495829,0.0004213909],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000105602,0.0007638271,0.001373083,0.003308613,0.0002461391,0.005114045,0.000004047203,7.845734e-9,0.00001718547,7.763301e-7,0.0001413416,0.9889253],"study_design_scores_gemma":[0.001351354,0.0002977831,0.008872434,0.03481311,0.0004102949,0.01959254,0.00001188946,0.00001200836,0.00001384957,0.0000317571,0.9344171,0.0001758413],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.007611774,0.9914295,0.000009715789,0.0001102735,0.0001903399,0.0003745478,0.000006095003,0.000007589423,0.0002601409],"genre_scores_gemma":[0.001445627,0.9969409,0.0007916319,0.00002392109,0.0002248353,0.00001121862,0.00002681323,0.00003318779,0.0005018606],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9887495,"threshold_uncertainty_score":0.6133054,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2007789733210437,"score_gpt":0.4477270501397253,"score_spread":0.2469480768186816,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}