{"id":"W2414204484","doi":"10.1038/srep13730","title":"Methylene Blue Inhibits Caspases by Oxidation of the Catalytic Cysteine","year":2015,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Trace Elements in Health","field":"Nursing","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Canadian Institutes of Health Research; Journal of Gastroenterology and Hepatology Foundation; Alzheimer Society; McGill University","keywords":"Methylene blue; Cysteine; Caspase; Recombinant DNA; Chemistry; Apoptosis; Biochemistry; Transfection; Molecular biology; Biology; Programmed cell death; Enzyme; Catalysis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002631415,0.0001203861,0.0001807632,0.0001085699,0.0002096023,0.00007944051,0.0001814752,0.00005726506,0.00001687104],"category_scores_gemma":[0.0009928385,0.00008872982,0.00005822064,0.0006950703,0.0002567545,0.0002231298,0.00009082998,0.0001104346,0.00001634241],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001888612,"about_ca_system_score_gemma":0.0001974712,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004583275,"about_ca_topic_score_gemma":0.0002102378,"domain_scores_codex":[0.9974832,0.0001309125,0.0006847775,0.0004940848,0.000915076,0.0002919545],"domain_scores_gemma":[0.9977097,0.00005263355,0.0006523438,0.001139968,0.0003063617,0.0001389717],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003330383,0.0002487669,0.01321244,0.0001264168,0.00001952623,0.00003145891,0.002903922,0.0002632911,0.6853587,0.00003493073,0.2909283,0.006838936],"study_design_scores_gemma":[0.0001843001,0.00006386686,0.0005611276,0.0000711192,0.00003188322,0.000113978,0.0002684259,0.00004677675,0.9551303,0.0009023793,0.04252606,0.00009974887],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9805844,0.0004664112,0.00005964544,0.0009617599,0.01695307,0.0004821399,0.00001014612,0.0000514507,0.0004309551],"genre_scores_gemma":[0.9968444,4.803609e-7,0.0003326293,0.00005521928,0.00006457871,0.00001171005,0.000066932,0.00001754445,0.002606502],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2697716,"threshold_uncertainty_score":0.3618297,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03134215240710247,"score_gpt":0.2994922705019196,"score_spread":0.2681501180948171,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}