{"id":"W2414504306","doi":"10.1158/1538-7445.am2015-3888","title":"Abstract 3888: Molecular profiling of sequential biopsies in patients with metastatic colorectal cancer identifies genomic alterations that evolve during first-line therapy and could have therapeutic implications: A prospective study to identify molecular mechanisms of clinical resistance (QCROC-01: NCT00984048).","year":2015,"lang":"en","type":"article","venue":"Cancer Research","topic":"Colorectal Cancer Treatments and Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mount Sinai Hospital; Hôpital Maisonneuve-Rosemont; Dr. Georges-L.-Dumont University Hospital Centre; Hôpital du Saint-Sacrement; Health Sciences Centre; Jewish General Hospital; Sunnybrook Health Science Centre; St Mary's Hospital Centre; McGill University; Hôpital du Sacré-Cœur de Montréal; Simon Fraser University; Hôtel-Dieu de Québec; Centre de Santé et de Services Sociaux de Chicoutimi; Hôpital Charles-Le Moyne; University of British Columbia; Quebec - Clinical Research Organization in Cancer","funders":"","keywords":"Colorectal cancer; Medicine; Bevacizumab; FOLFOX; Oxaliplatin; Oncology; Internal medicine; Somatic evolution in cancer; Liquid biopsy; Biopsy; KRAS; Cancer; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003836605,0.0001852265,0.0002675234,0.0002888481,0.0002287199,0.0003102834,0.000193979,0.0003060869,0.002244577],"category_scores_gemma":[0.000775992,0.0001364867,0.0001378262,0.0003049178,0.0001420342,0.0001305323,0.0001737867,0.0002882025,0.0004315404],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002166343,"about_ca_system_score_gemma":0.0002039175,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000908604,"about_ca_topic_score_gemma":0.002113433,"domain_scores_codex":[0.9997573,0.00006968263,0.00002059746,0.00006528633,0.00005537662,0.00003158809],"domain_scores_gemma":[0.9995944,0.00007237126,0.000109036,0.00003538464,0.00009553433,0.00009322993],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.008619076,0.0006686201,0.7766104,0.0001765797,0.0001322183,0.0008762265,0.0001711804,0.0002899644,0.1844954,0.00007528772,0.001871104,0.02601394],"study_design_scores_gemma":[0.0002012274,0.003316519,0.9782017,0.000009534111,0.00005670582,0.001851488,0.0001034169,0.0005886275,0.01378294,0.00003148152,0.001847439,0.000008819982],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975868,0.0002956476,0.0003291309,0.00005683357,0.000008660668,0.00008606314,0.001189838,0.00001624402,0.000430792],"genre_scores_gemma":[0.9959604,0.0001073836,0.0009557193,0.00008121011,0.000008962649,0.00009176703,0.00197128,0.000007532452,0.0008157809],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002244577,"threshold_uncertainty_score":0.007508934,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1541721781435665,"score_gpt":0.4673843036645816,"score_spread":0.3132121255210151,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}