{"id":"W2414507880","doi":"10.1136/annrheumdis-2015-eular.3582","title":"THU0432 Long-Term (104-Week) Safety Profile of Apremilast, An Oral Phosphodiesterase 4 Inhibitor, In Patients with Psoriatic Arthritis: Pooled Safety Analysis of Three Phase 3, Randomized, Controlled Trials","year":2015,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Synthesis of β-Lactam Compounds","field":"Chemistry","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto Western Hospital","funders":"IC Design Education Center; AbbVie; Genentech; Celgene; Biogen; Amgen; Pfizer; Eli Lilly and Company","keywords":"Medicine; Apremilast; Tolerability; Psoriatic arthritis; Internal medicine; Placebo; Adverse effect; Nausea; Randomized controlled trial; Gastroenterology; Surgery; Arthritis; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005209353,0.001339282,0.003768096,0.0008244307,0.0003790774,0.00122485,0.0006700612,0.001529813,0.002943675],"category_scores_gemma":[0.003307051,0.0007583509,0.005142382,0.0007608656,0.0007202924,0.001045133,0.0003866323,0.002227754,0.0005252055],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005359286,"about_ca_system_score_gemma":0.001000083,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004602668,"about_ca_topic_score_gemma":0.00150255,"domain_scores_codex":[0.9982449,0.001100305,0.0001604776,0.0001835895,0.0001888185,0.0001218267],"domain_scores_gemma":[0.9982818,0.0006642045,0.0005283859,0.0001396908,0.0001663667,0.0002195308],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.8443611,0.00342624,0.002987664,0.004654183,0.02642771,0.0001183935,0.00008458729,0.00171468,0.01458718,0.0001260203,0.001713264,0.09979884],"study_design_scores_gemma":[0.7459628,0.2016738,0.01862945,0.0002971484,0.02414242,0.0003958422,0.00007978807,0.001629774,0.003816012,0.0002832769,0.00299828,0.00009146491],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9208257,0.06820784,0.002896216,0.0008541528,0.0005324059,0.001629063,0.002125805,0.0003202475,0.002608574],"genre_scores_gemma":[0.9782276,0.01430955,0.001822145,0.0008965935,0.0004377861,0.001026357,0.001522782,0.00003266633,0.001724451],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005209353,"threshold_uncertainty_score":0.02755004,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04379262440363482,"score_gpt":0.3056959914613972,"score_spread":0.2619033670577624,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}