{"id":"W2414507880","doi":"10.1136/annrheumdis-2015-eular.3582","title":"THU0432 Long-Term (104-Week) Safety Profile of Apremilast, An Oral Phosphodiesterase 4 Inhibitor, In Patients with Psoriatic Arthritis: Pooled Safety Analysis of Three Phase 3, Randomized, Controlled Trials","year":2015,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Synthesis of β-Lactam Compounds","field":"Chemistry","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto Western Hospital","funders":"IC Design Education Center; AbbVie; Genentech; Celgene; Biogen; Amgen; Pfizer; Eli Lilly and Company","keywords":"Medicine; Apremilast; Tolerability; Psoriatic arthritis; Internal medicine; Placebo; Adverse effect; Nausea; Randomized controlled trial; Gastroenterology; Surgery; Arthritis; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.004251152,0.0005645051,0.007479236,0.0004096419,0.00007142467,0.00005233723,0.0008442851,0.0001405562,0.0006574243],"category_scores_gemma":[0.01210856,0.0003432443,0.001857491,0.0007209113,0.0005240884,0.0004240006,0.0001816541,0.0001483154,0.000002284603],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006601874,"about_ca_system_score_gemma":0.0004177539,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002358383,"about_ca_topic_score_gemma":0.0002191211,"domain_scores_codex":[0.9920293,0.0015264,0.004114298,0.000473317,0.001411159,0.0004455099],"domain_scores_gemma":[0.9885896,0.004760875,0.00402754,0.001472553,0.0008273106,0.0003221501],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7348151,0.01507651,0.1757336,0.001146603,0.02409504,0.000006506271,0.00111382,0.001643933,0.0001594348,0.00008040029,0.0002724546,0.04585663],"study_design_scores_gemma":[0.8416075,0.0007533745,0.101962,0.007450523,0.02091941,0.000001190584,0.0005681702,0.009115638,0.01546624,0.001233428,0.000003169126,0.0009194037],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931885,0.00275546,0.000124517,0.0001110926,0.0001216164,0.001946194,0.0014223,0.00004016179,0.0002901843],"genre_scores_gemma":[0.9989275,0.0002430859,0.0001752384,0.00003302612,0.00003138961,0.000207274,0.0003016978,0.0000492041,0.00003159224],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1067924,"threshold_uncertainty_score":0.999902,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04379262440363482,"score_gpt":0.3056959914613972,"score_spread":0.2619033670577624,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}