{"id":"W2414771725","doi":"10.1186/s13059-016-0971-7","title":"Single-cell sequencing reveals karyotype heterogeneity in murine and human malignancies","year":2016,"lang":"en","type":"article","venue":"Genome biology","topic":"Genomic variations and chromosomal abnormalities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":278,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"Universitair Medisch Centrum Groningen; KWF Kankerbestrijding; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Ministry of Earth Sciences; Rijksuniversiteit Groningen","keywords":"Chromosome instability; Biology; Karyotype; Genome instability; Aneuploidy; Genetics; Chromosome; Chromothripsis; Copy-number variation; Genome; Gene; DNA; DNA damage","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002809453,0.000228825,0.0002045422,0.0006652232,0.0001168697,0.0002895556,0.0001758296,0.0004244549,0.0009679381],"category_scores_gemma":[0.0004240488,0.00014812,0.0001947179,0.0003122524,0.0001707619,0.0001632242,0.0002685607,0.0002150019,0.0003527176],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002073939,"about_ca_system_score_gemma":0.00009172331,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003750707,"about_ca_topic_score_gemma":0.0007906341,"domain_scores_codex":[0.9997957,0.00001848852,0.00001326579,0.00008016845,0.00007277713,0.00001958889],"domain_scores_gemma":[0.9997095,0.00009656222,0.00006530581,0.00005376707,0.00004361609,0.00003116599],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00006572928,0.000006959588,0.00255742,0.00003508776,0.00001512053,0.00005348071,0.00002448644,0.0002749457,0.9915168,0.00007967842,0.00008487493,0.005285397],"study_design_scores_gemma":[0.00001428082,0.0003111314,0.08151893,0.00001602146,0.00007272118,0.001636616,0.0000408394,0.007065049,0.9034958,0.0005062628,0.00530599,0.00001631236],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9653207,0.002044289,0.02792481,0.00008720828,0.00001619974,0.00005872748,0.002886115,0.0005771494,0.001084765],"genre_scores_gemma":[0.9761668,0.0009131355,0.01715181,0.0001088837,0.000008936848,0.00009768074,0.004255117,0.0001261315,0.001171362],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009679381,"threshold_uncertainty_score":0.003238142,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01920264595537637,"score_gpt":0.2313056946727422,"score_spread":0.2121030487173658,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}