{"id":"W2414771725","doi":"10.1186/s13059-016-0971-7","title":"Single-cell sequencing reveals karyotype heterogeneity in murine and human malignancies","year":2016,"lang":"en","type":"article","venue":"Genome biology","topic":"Genomic variations and chromosomal abnormalities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":278,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"Universitair Medisch Centrum Groningen; KWF Kankerbestrijding; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Ministry of Earth Sciences; Rijksuniversiteit Groningen","keywords":"Chromosome instability; Biology; Karyotype; Genome instability; Aneuploidy; Genetics; Chromosome; Chromothripsis; Copy-number variation; Genome; Gene; DNA; DNA damage","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001550378,0.000131888,0.0001541344,0.00005359999,0.00006611271,0.000009143268,0.0001166007,0.0001418404,0.00004069975],"category_scores_gemma":[0.00001892619,0.0000995575,0.00003589758,0.00003968193,0.0001087797,0.000003928561,0.0001510091,0.00003330559,0.00001184379],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004092806,"about_ca_system_score_gemma":0.0000311683,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006338915,"about_ca_topic_score_gemma":0.0001590812,"domain_scores_codex":[0.9990817,0.00007545979,0.0002232748,0.0003174183,0.00002655235,0.0002756065],"domain_scores_gemma":[0.9996122,0.00001155543,0.00006938864,0.0002226214,0.00003357389,0.00005068943],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001160038,0.00001952762,0.08943277,0.0000117092,0.00001007744,0.000002450585,0.00003745076,0.000001476307,0.9097531,0.0005403783,0.00001304821,0.0001664084],"study_design_scores_gemma":[0.001342393,0.001063692,0.1736026,0.00002392775,0.00001481905,0.00007961806,0.0001284641,5.818383e-7,0.7994415,0.001959079,0.02185082,0.0004924661],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977111,0.0009528673,0.0001634563,0.0001005506,0.00006267948,0.00009909293,0.00005089759,0.000009569485,0.0008497852],"genre_scores_gemma":[0.9982337,0.0001274457,0.0003668856,0.0001318205,0.0001391754,0.00001599003,0.00005919487,0.00001267737,0.0009130844],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1103116,"threshold_uncertainty_score":0.4059837,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01920264595537637,"score_gpt":0.2313056946727422,"score_spread":0.2121030487173658,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}