{"id":"W2414891484","doi":"10.1093/carcin/bgw070","title":"Genetic variant in DNA repair gene<i>GTF2H4</i>is associated with lung cancer risk: a large-scale analysis of six published GWAS datasets in the TRICL consortium","year":2016,"lang":"en","type":"article","venue":"Carcinogenesis","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute","funders":"Canadian Cancer Society Research Institute; National Cancer Institute; National Institutes of Health; Cancer Research UK; National Human Genome Research Institute; World Health Organization","keywords":"Odds ratio; Single-nucleotide polymorphism; Genome-wide association study; Lung cancer; Cancer; Internal medicine; Oncology; Genetic association; Medicine; DNA repair; Genetics; Biology; Bioinformatics; Genotype; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006539892,0.0001986337,0.0003703255,0.0002570292,0.00007125321,0.00002431244,0.0003993372,0.0001629442,0.0001096241],"category_scores_gemma":[0.0001533174,0.0001222206,0.000192688,0.001205217,0.00009649053,0.00001241612,0.00007524934,0.00007220347,8.475867e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008404185,"about_ca_system_score_gemma":0.0002294626,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001089301,"about_ca_topic_score_gemma":0.01020216,"domain_scores_codex":[0.9979996,0.000317554,0.0004612321,0.0005984551,0.0002531855,0.000369941],"domain_scores_gemma":[0.9983984,0.00006620331,0.0002904409,0.001020706,0.0001567821,0.00006749608],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001066948,0.0002033999,0.9191235,0.0000112123,0.0008004027,0.00002029909,0.0002932941,0.0004962815,0.07511245,0.000004794185,0.003304699,0.0005230288],"study_design_scores_gemma":[0.001380993,0.00006553563,0.9601315,0.00002464368,0.00105107,0.000003917923,0.0001272792,0.001322743,0.0340278,0.000004147206,0.001621832,0.0002384938],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917292,0.003268326,0.0008044763,0.0002676054,0.00003977794,0.000312868,0.003513256,0.000009141923,0.00005532521],"genre_scores_gemma":[0.9975644,0.001167691,0.0001499775,0.0002717647,0.00004686152,0.0002450557,0.0004280307,0.00002214882,0.000104026],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04108465,"threshold_uncertainty_score":0.5693042,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008692868519116931,"score_gpt":0.247818293853684,"score_spread":0.239125425334567,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}