{"id":"W2415009490","doi":"10.1177/135965350501000801","title":"TAK-652, a Novel CCR5 Inhibitor, has Favourable Drug Interactions with other Antiretrovirals <i>in Vitro</i>","year":2005,"lang":"en","type":"letter","venue":"Antiviral Therapy","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"","keywords":"Pharmacology; Drug; Protease inhibitor (pharmacology); CCR5 receptor antagonist; In vitro; Medicine; Human immunodeficiency virus (HIV); Chemistry; Internal medicine; Antiretroviral therapy; Virology; Viral load; Inflammation; Chemokine receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001243318,0.0008423023,0.001354795,0.0002704235,0.001994692,0.001861982,0.0008122714,0.02191737,0.00308326],"category_scores_gemma":[0.006745251,0.0003158501,0.001289666,0.0003101915,0.001005605,0.001404569,0.0003873238,0.01347622,0.002880046],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002595614,"about_ca_system_score_gemma":0.001433641,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003238898,"about_ca_topic_score_gemma":0.006767315,"domain_scores_codex":[0.9988564,0.0003028474,0.0001430617,0.0001112661,0.0003898322,0.000196559],"domain_scores_gemma":[0.9981405,0.001264789,0.0001192886,0.00004327402,0.0002385325,0.0001935767],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005530495,0.0001400859,0.001816034,0.0002130872,0.00005800844,0.0305561,0.0001629135,0.0004348323,0.001922446,0.004763519,0.9167086,0.04267122],"study_design_scores_gemma":[0.001001296,0.001082072,0.004073305,0.0002983271,0.0001504098,0.04211396,0.0004993841,0.002744508,0.003179112,0.008988477,0.9357634,0.0001057789],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.005964056,0.003459772,0.0005559933,0.9554639,0.01961917,0.00003702649,0.0001397225,0.00006553655,0.01469477],"genre_scores_gemma":[0.0447281,0.005983311,0.001481042,0.8714514,0.04670243,0.0000927188,0.0001809923,0.0000475035,0.02933248],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.02191737,"threshold_uncertainty_score":0.01883262,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03081082085888891,"score_gpt":0.2673798028364486,"score_spread":0.2365689819775597,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}