{"id":"W2415049193","doi":"10.1177/135965350400900414","title":"Predictive Value of HIV-1 Protease Genotype and Virtual Phenotype on the Virological Response to Lopinavir/Ritonavir-Containing Salvage Regimens","year":2004,"lang":"en","type":"article","venue":"Antiviral Therapy","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"AIDS Vancouver; University Health Network; McGill University; University of Toronto; Montreal General Hospital","funders":"","keywords":"Lopinavir; Lopinavir/ritonavir; Ritonavir; Internal medicine; Virology; Viral load; Regimen; Odds ratio; Population; Univariate analysis; Genotype; Salvage therapy; Biology; Medicine; Oncology; Immunology; Multivariate analysis; Human immunodeficiency virus (HIV); Genetics; Antiretroviral therapy; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005229829,0.0002571314,0.000362698,0.0001053446,0.0001513055,0.00001665269,0.0001130044,0.0001043906,0.00003120647],"category_scores_gemma":[0.0001343691,0.0001537159,0.00008552917,0.0002248174,0.0001830587,0.00006688826,0.00005073815,0.0002293436,0.00009141113],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009371269,"about_ca_system_score_gemma":0.0001530056,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001807171,"about_ca_topic_score_gemma":0.000001345197,"domain_scores_codex":[0.9985087,0.0002291793,0.0002583066,0.0003784336,0.0003258966,0.0002995172],"domain_scores_gemma":[0.9991758,0.0002510372,0.00008698899,0.0003167394,0.00005859341,0.0001108237],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.2424036,0.004092013,0.08000262,0.00004556761,0.001733894,0.001166352,0.03350299,0.0001693985,0.5459183,0.04510872,0.001535996,0.04432048],"study_design_scores_gemma":[0.018134,0.02971718,0.737551,0.0007196058,0.0001806977,0.00005115192,0.001777247,0.00008492078,0.1964869,0.002737082,0.0117821,0.0007780546],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9850572,0.0001959434,0.0002592134,0.0122367,0.00005073451,0.001387814,0.00002155543,0.00006004455,0.0007308003],"genre_scores_gemma":[0.9960331,0.000112631,0.0008163519,0.001512635,0.00008364849,0.00008874658,0.00001510823,0.0000292744,0.001308535],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6575484,"threshold_uncertainty_score":0.6268353,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02116568627766399,"score_gpt":0.2760755676495867,"score_spread":0.2549098813719227,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}