{"id":"W2415084109","doi":"10.1002/mbo3.381","title":"Protein engineering of <i>Saccharomyces cerevisiae</i> transporter Pdr5p identifies key residues that impact <i>Fusarium</i> mycotoxin export and resistance to inhibition","year":2016,"lang":"en","type":"article","venue":"MicrobiologyOpen","topic":"Mycotoxins in Agriculture and Food","field":"Agricultural and Biological Sciences","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University; University of Ottawa; Agriculture and Agri-Food Canada","funders":"Agriculture and Agri-Food Canada","keywords":"Mycotoxin; ATP-binding cassette transporter; Biology; Fusarium; Trichothecene; Yeast; Saccharomyces cerevisiae; Multiple drug resistance; Microbiology; Biotechnology; Food science; Transporter; Drug resistance; Gene; Botany; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009325765,0.0003471078,0.0001463418,0.0001009684,0.0001246727,0.0002965576,0.0002332851,0.000231968,0.0009322353],"category_scores_gemma":[0.0001050768,0.00009866869,0.0002222813,0.0001452767,0.000168129,0.0001317525,0.0001937393,0.0002852325,0.0004251309],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003513215,"about_ca_system_score_gemma":0.0002074026,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001368907,"about_ca_topic_score_gemma":0.001436907,"domain_scores_codex":[0.9999162,0.00001484996,0.0000129472,0.00001794033,0.00002321275,0.00001474758],"domain_scores_gemma":[0.99993,0.00001014933,0.00002913241,0.000007741281,0.000008254025,0.0000147989],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008813076,0.00002268204,0.0002597889,0.0000370156,0.000007021743,0.00007411903,0.00001082495,0.0001721944,0.9979213,0.000169481,0.00004973906,0.00118776],"study_design_scores_gemma":[0.00001225254,0.00008855276,0.001976423,0.000006284204,0.00002105046,0.0001896769,0.000024907,0.001514236,0.9917951,0.00003695063,0.004329531,0.000005065745],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901727,0.0004943319,0.006833983,0.0001096918,0.00003086612,0.00003376908,0.0006531797,0.0001785797,0.001492927],"genre_scores_gemma":[0.9914473,0.0003855883,0.005353401,0.00005244227,0.000003824643,0.00001173113,0.001021649,0.00007749327,0.001646659],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001368907,"threshold_uncertainty_score":0.003118694,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01076773704128423,"score_gpt":0.1999385572661404,"score_spread":0.1891708202248562,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}