{"id":"W2415197840","doi":"10.1007/978-1-61779-204-5_2","title":"The Prohormone Theory and the Proprotein Convertases: It Is All About Serendipity","year":2011,"lang":"en","type":"review","venue":"Methods in molecular biology","topic":"Biotin and Related Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital","funders":"","keywords":"Proprotein Convertases; Serendipity; Prohormone; Hormone; Biology; Endocrinology; Philosophy; Epistemology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.005341507,0.0005968866,0.001273108,0.0000673578,0.0002410873,0.0000351064,0.0007976293,0.001279969,0.00001735883],"category_scores_gemma":[0.0009032568,0.0002732501,0.0004574591,0.0001687724,0.001999046,0.000001433829,0.0008247972,0.0008783255,0.000009560258],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001899217,"about_ca_system_score_gemma":0.0001338835,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000431266,"about_ca_topic_score_gemma":0.00002102159,"domain_scores_codex":[0.9899729,0.00784676,0.0007186935,0.0008354282,0.00007342924,0.0005527214],"domain_scores_gemma":[0.9980425,0.0004450631,0.0004067692,0.0009701409,0.00006787087,0.0000676892],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000266068,0.00005083165,0.000003589936,0.001091605,0.002041227,0.00001150236,0.0002503013,3.580376e-8,0.001384668,0.02277622,0.001030631,0.9710933],"study_design_scores_gemma":[0.0005850555,0.000161202,0.00000146285,0.0002375863,0.0008053611,0.0000667619,0.00005810644,0.000001175463,0.002164452,0.006385088,0.9891498,0.0003839582],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000004628252,0.976465,0.01953,0.0004027788,0.0002533354,0.001845521,0.00003825604,0.0000119963,0.001448509],"genre_scores_gemma":[0.000003133784,0.9787423,0.01801526,0.001300858,0.00007544219,0.0005946853,0.00006087979,0.00005771096,0.001149716],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9881192,"threshold_uncertainty_score":0.999972,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03515517676804276,"score_gpt":0.4116274615477353,"score_spread":0.3764722847796925,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}