{"id":"W2415347727","doi":"10.1385/1-59259-182-5:163","title":"Extracting DNA Demethylase Activity from Mammalian Cells","year":2003,"lang":"en","type":"article","venue":"Humana Press eBooks","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Cancer Institute; Medical Research Council Canada","keywords":"Demethylation; DNA demethylation; Cytosine; DNA; Chemistry; Demethylase; DNA glycosylase; Base excision repair; Nucleotide; Cleavage (geology); CpG site; Uracil; DNA methylation; Biochemistry; Stereochemistry; DNA repair; Biology; Gene; Gene expression; Histone","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002148737,0.0001700919,0.0001297448,0.00002533618,0.0001339842,0.00005191766,0.0001391388,0.0001664358,0.00003987874],"category_scores_gemma":[0.00005964519,0.0001800243,0.00008595809,0.000009735038,0.00004587376,0.000003602148,0.00005842556,0.0001173318,0.000007760324],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001044889,"about_ca_system_score_gemma":0.00002979755,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000281792,"about_ca_topic_score_gemma":0.0001277394,"domain_scores_codex":[0.9988775,0.0001706931,0.0001728491,0.0003937685,0.0001343773,0.0002507715],"domain_scores_gemma":[0.9992673,0.00003003424,0.0001193658,0.0004349732,0.00004803055,0.0001002275],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002178899,0.00003324475,0.00005235863,0.000008202799,0.00003297159,0.000004434307,0.0000657491,0.00003900948,0.9717368,0.000341045,0.0001266064,0.02753779],"study_design_scores_gemma":[0.0002736392,0.00005150837,0.0004196315,0.000004618785,0.00002248703,3.895498e-7,0.00001295654,0.000020193,0.8160568,0.0003357149,0.1826228,0.000179308],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9483971,0.00316106,0.0033069,0.000004192917,0.000252478,0.0001690366,0.0000208445,0.0000189083,0.04466947],"genre_scores_gemma":[0.9952852,0.0001399886,0.001450421,0.00004316945,0.0002186545,0.00002053451,0.0000266377,0.00003249786,0.002782968],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1824962,"threshold_uncertainty_score":0.7341179,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04255556832811746,"score_gpt":0.2751377477659988,"score_spread":0.2325821794378813,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}