{"id":"W2415466344","doi":"10.1139/cjpp-2015-0572","title":"Pretreatment with Astragaloside IV protects human umbilical vein endothelial cells from hydrogen peroxide induced oxidative stress and cell dysfunction via inhibiting eNOS uncoupling and NADPH oxidase – ROS – NF-κB pathway","year":2016,"lang":"en","type":"article","venue":"Canadian Journal of Physiology and Pharmacology","topic":"Traditional Chinese Medicine Analysis","field":"Medicine","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Natural Science Foundation of China","keywords":"Oxidative stress; Umbilical vein; NADPH oxidase; Hydrogen peroxide; Enos; Reactive oxygen species; Chemistry; Nitric oxide; Oxidative phosphorylation; Human umbilical vein endothelial cell; Endothelial stem cell; Biochemistry; Cell biology; Biology; Nitric oxide synthase; Enzyme; In vitro","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001814175,0.0002470823,0.0005429088,0.000251388,0.000238572,0.000009305119,0.00005783252,0.0001563566,0.0002955023],"category_scores_gemma":[0.00003422824,0.0001596881,0.00005598936,0.00009489657,0.0003760338,0.0001309862,0.0000164396,0.0004277321,0.000001766574],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001404568,"about_ca_system_score_gemma":0.0004249036,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002160308,"about_ca_topic_score_gemma":0.003302904,"domain_scores_codex":[0.9986485,0.0001962708,0.0003657716,0.0003435524,0.0001234434,0.0003225111],"domain_scores_gemma":[0.9984555,0.0002990025,0.0002891454,0.00008245705,0.000148184,0.000725719],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000455068,0.00008113698,0.004576336,0.00007219638,0.0004002851,0.0005097558,0.0004603295,0.00001758705,0.9925122,0.000007191322,0.00002893075,0.0008789662],"study_design_scores_gemma":[0.00570597,0.002358308,0.01579998,0.0001923674,0.0004989929,0.000298298,0.0001353362,0.00005993457,0.9743691,0.000386249,0.00003718902,0.0001582505],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983644,0.0002726693,0.0000910168,0.0006376524,0.00009657276,0.0003613902,0.0001418802,0.000007721602,0.00002671727],"genre_scores_gemma":[0.9988286,0.00003186154,0.0001498739,0.0003102551,0.000584117,0.00002037068,0.00002878563,0.00002212818,0.00002398324],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0181431,"threshold_uncertainty_score":0.6511893,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0119139762050894,"score_gpt":0.2347520842956301,"score_spread":0.2228381080905407,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}