{"id":"W2415636816","doi":"10.1007/s10637-016-0367-2","title":"Phase I trial of dacomitinib, a pan-human epidermal growth factor receptor (HER) inhibitor, with concurrent radiotherapy and cisplatin in patients with locoregionally advanced squamous cell carcinoma of the head and neck (XDC-001)","year":2016,"lang":"en","type":"article","venue":"Investigational New Drugs","topic":"Head and Neck Cancer Studies","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network; Princess Margaret Cancer Centre; University of Toronto","funders":"Pfizer","keywords":"Cisplatin; Epidermal growth factor receptor; Oncology; Medicine; Head and neck; Radiation therapy; Head and neck squamous-cell carcinoma; Internal medicine; Basal cell; Cancer research; Chemotherapy; Carcinoma; Head and neck cancer; Receptor; Surgery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008627361,0.0002096929,0.0004732338,0.0000785691,0.00006212287,0.000005584602,0.00006656011,0.00005706596,0.00002866664],"category_scores_gemma":[0.00008065207,0.0001124294,0.00003787387,0.0001542288,0.0005705405,0.0001160163,0.00002998035,0.0001201077,3.334514e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007456822,"about_ca_system_score_gemma":0.0004109408,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001543278,"about_ca_topic_score_gemma":0.00006810172,"domain_scores_codex":[0.9985468,0.00007675555,0.0004494794,0.0002904114,0.0004508997,0.0001856077],"domain_scores_gemma":[0.998929,0.0002806366,0.0002998883,0.0001429568,0.0001787329,0.0001687543],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0233317,0.001856389,0.9389158,0.0002704314,0.00007234067,0.000003230426,0.003156591,0.000001590414,0.01538706,0.0006433838,0.001434563,0.01492693],"study_design_scores_gemma":[0.2922471,0.008453663,0.6859481,0.0007229013,0.00003937933,0.000003275494,0.00006499018,0.000009129878,0.01163847,0.0001448732,0.0005217142,0.0002064739],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961561,0.000322525,0.00001000225,0.002196011,0.00007613927,0.001021397,0.0001337373,0.000008497082,0.00007561313],"genre_scores_gemma":[0.9987841,0.00002306821,0.0005588961,0.0003066525,0.0001237028,0.00003616431,0.0000301522,0.00002223068,0.0001150362],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2689154,"threshold_uncertainty_score":0.4584739,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01778624658383064,"score_gpt":0.2729515223007116,"score_spread":0.255165275716881,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}