{"id":"W2415698085","doi":"10.1371/journal.pone.0157230","title":"Trafficking Dynamics of PCSK9-Induced LDLR Degradation: Focus on Human PCSK9 Mutations and C-Terminal Domain","year":2016,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Heart Institute; Université de Montréal","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Institut de Cardiologie de Montréal; Fondation Institut de Cardiologie de Montréal; Institute of Nutrition, Metabolism and Diabetes; Heart and Stroke Foundation of Canada","keywords":"LDL receptor; PCSK9; Cell biology; Endocytosis; Endoplasmic reticulum; Endocytic cycle; Fluorescence recovery after photobleaching; Biology; Receptor; Biochemistry; Cholesterol; Lipoprotein","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006605826,0.000154818,0.000126611,0.0001005757,0.00009750951,0.00014393,0.0001261843,0.0002043479,0.0006003441],"category_scores_gemma":[0.00006268622,0.00008458619,0.0002419074,0.00009295525,0.0001227023,0.0001774133,0.00014164,0.0003470677,0.0002976705],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003693135,"about_ca_system_score_gemma":0.00012296,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001429204,"about_ca_topic_score_gemma":0.0007843964,"domain_scores_codex":[0.9999305,0.000006633873,0.00000711613,0.00002484394,0.00001378639,0.00001709647],"domain_scores_gemma":[0.9999578,0.000006443389,0.00001307859,0.000006149422,0.00000811983,0.00000836725],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001725031,0.00001578215,0.0003224372,0.00002514756,0.000004216332,0.000077227,0.00001749813,0.0001404175,0.9978967,0.00008129554,0.0000499667,0.00119687],"study_design_scores_gemma":[0.000007081189,0.00007099219,0.005217337,0.000003916646,0.00001009384,0.0003327063,0.00002012148,0.003567214,0.9897001,0.00004030603,0.001024576,0.00000559362],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964946,0.00066282,0.001922464,0.00005916095,0.00000914633,0.000009044636,0.0003486358,0.0000385094,0.0004557011],"genre_scores_gemma":[0.9949464,0.0007446912,0.001913274,0.00003812551,0.00000369849,0.00001691914,0.0004728487,0.00002269033,0.001841391],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001429204,"threshold_uncertainty_score":0.002841771,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05604166675105647,"score_gpt":0.2800887394752601,"score_spread":0.2240470727242036,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}