{"id":"W2415889477","doi":"10.1016/j.biomaterials.2016.06.016","title":"A drug delivery hydrogel system based on activin B for Parkinson's disease","year":2016,"lang":"en","type":"article","venue":"Biomaterials","topic":"Nerve injury and regeneration","field":"Neuroscience","cited_by":56,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba; Children's Hospital Research Institute of Manitoba","funders":"Science and Technology Planning Project of Guangdong Province; National Key Research and Development Program of China; Natural Science Foundation of Guangdong Province; National Natural Science Foundation of China","keywords":"Self-healing hydrogels; Neuroprotection; Striatum; Drug delivery; Microglia; Pharmacology; TGF beta signaling pathway; Tyrosine hydroxylase; Materials science; Transforming growth factor; Cancer research; Medicine; Endocrinology; Inflammation; Internal medicine; Nanotechnology; Dopamine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002375519,0.0001312745,0.0001412844,0.0000678037,0.0001580717,0.0000663286,0.0001421864,0.00004081868,0.00003842779],"category_scores_gemma":[0.0001440711,0.00007838774,0.00007882186,0.00005557354,0.00004852113,0.0001360159,0.00001925237,0.000003140567,0.0001210333],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006372484,"about_ca_system_score_gemma":0.00005310038,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004646435,"about_ca_topic_score_gemma":0.000001187545,"domain_scores_codex":[0.9989075,0.000161675,0.0001861581,0.0003629878,0.0001570488,0.0002246429],"domain_scores_gemma":[0.999255,0.0002351432,0.0001086495,0.0002663792,0.00001914365,0.0001156636],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005707866,0.00005727119,0.00003049184,0.00007113168,0.000001663346,0.000010841,0.000004931853,0.000003094351,0.9963316,0.001018943,0.001143114,0.0007561755],"study_design_scores_gemma":[0.0005802162,0.00006187582,0.0001359552,0.0001339508,0.00001109825,0.000001247169,0.000001889979,0.000525397,0.9903871,0.00008206287,0.007942786,0.0001364451],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961902,0.000007392866,0.0005546293,0.0006094259,0.001299992,0.0005007531,0.0005982161,0.0001732558,0.00006614492],"genre_scores_gemma":[0.998741,0.000002635652,0.00007299289,0.0002770905,0.0003454821,0.0002106978,0.000007023448,0.00002062622,0.0003224066],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006799672,"threshold_uncertainty_score":0.3196559,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02744320177404398,"score_gpt":0.2544652770270507,"score_spread":0.2270220752530067,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}