{"id":"W2416161884","doi":"10.3390/molecules21060737","title":"Synthesis, Anti-HCV, Antioxidant and Reduction of Intracellular Reactive Oxygen Species Generation of a Chlorogenic Acid Analogue with an Amide Bond Replacing the Ester Bond","year":2016,"lang":"en","type":"article","venue":"Molecules","topic":"Coffee research and impacts","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland","funders":"Shanghai Medical College, Fudan University; Peking University; Natural Science Foundation of Inner Mongolia; Inner Mongolia University; Fudan University","keywords":"Chlorogenic acid; Caffeic acid; Quinic acid; Chemistry; Amide; Antioxidant; Peptide bond; Phenolic acid; Biochemistry; Stereochemistry; Amino acid; Food science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001670562,0.0003754461,0.0002771163,0.0002777933,0.000171198,0.0001567426,0.000195083,0.0002383473,0.0009714211],"category_scores_gemma":[0.0001064954,0.0001363189,0.0004083186,0.0001888931,0.0001752713,0.0002028005,0.0001507946,0.000300504,0.0002332268],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001409024,"about_ca_system_score_gemma":0.0001768289,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005724928,"about_ca_topic_score_gemma":0.0008922848,"domain_scores_codex":[0.9999307,0.00001354927,0.000006066809,0.00001469688,0.00001416559,0.00002068742],"domain_scores_gemma":[0.9999267,0.000005527696,0.0000170189,0.00001036513,0.00001678083,0.00002355782],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001694616,0.00004005258,0.00006598291,0.0001210135,0.00001208829,0.000129635,0.00001849297,0.0001532731,0.9972658,0.0001110367,0.00002558287,0.001887527],"study_design_scores_gemma":[0.00004977392,0.00109322,0.001072024,0.000009650376,0.00003789288,0.0002157662,0.00001162267,0.0002271874,0.9930679,0.00003806108,0.004165213,0.00001181105],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9776598,0.007171138,0.008555413,0.0001745167,0.00009675264,0.0002207322,0.0006365916,0.00009956138,0.005385557],"genre_scores_gemma":[0.9905615,0.00200014,0.005485456,0.00005898801,0.00002189572,0.00004079485,0.0003154729,0.00001564639,0.001500085],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009714211,"threshold_uncertainty_score":0.003249705,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02829928506273219,"score_gpt":0.2590118417685698,"score_spread":0.2307125567058377,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}