{"id":"W2416325988","doi":"10.1126/science.aaf6419","title":"Zebrafish models of idiopathic scoliosis link cerebrospinal fluid flow defects to spine curvature","year":2016,"lang":"en","type":"article","venue":"Science","topic":"Genetic and Kidney Cyst Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":308,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; Canada Research Chairs; Canadian Institutes of Health Research; March of Dimes Foundation","keywords":"Cerebrospinal fluid; Zebrafish; Spinal Curvatures; Motile cilium; Cilium; Scoliosis; Idiopathic scoliosis; Anatomy; Curvature; Fish <Actinopterygii>; Mechanism (biology); SPINE (molecular biology); Fluid dynamics; Medicine; Biology; Neuroscience; Mechanics; Cell biology; Physics; Surgery; Geometry; Mathematics; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002620405,0.0001260544,0.0001299938,0.00007183258,0.00009622709,0.00002141303,0.0004776007,0.00007856973,0.000008527465],"category_scores_gemma":[0.0003347873,0.0000889622,0.00007380213,0.0003564572,0.0003262222,0.00001158391,0.0002176243,0.00003222808,0.00001712475],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000135812,"about_ca_system_score_gemma":0.0004151839,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003220144,"about_ca_topic_score_gemma":0.000003516089,"domain_scores_codex":[0.9987252,0.00002194574,0.0001635612,0.0004571899,0.0003002904,0.0003317899],"domain_scores_gemma":[0.9989678,0.000001700657,0.00005157631,0.0004507042,0.0002158794,0.0003123328],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002740062,0.0000248251,0.0008719416,0.00002095646,0.000004304813,8.177494e-7,0.00001977915,0.0001263651,0.996734,0.00008650729,0.0003185628,0.00176451],"study_design_scores_gemma":[0.0003200564,0.000479409,0.02417828,0.0002097294,0.00001354866,0.000005684996,0.000009523129,0.000207312,0.9724744,0.0007386701,0.001178405,0.0001850086],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9806046,0.001909347,0.01587942,0.0006975995,0.0002227805,0.0001822326,0.00003132357,0.00001264851,0.0004600082],"genre_scores_gemma":[0.9969189,0.0000663215,0.002027364,0.0006472431,0.0001637558,0.00001385862,0.00000178817,0.00001015456,0.0001506549],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02425965,"threshold_uncertainty_score":0.3627773,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00880477874276999,"score_gpt":0.2393109660282522,"score_spread":0.2305061872854822,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}