{"id":"W2416325988","doi":"10.1126/science.aaf6419","title":"Zebrafish models of idiopathic scoliosis link cerebrospinal fluid flow defects to spine curvature","year":2016,"lang":"en","type":"article","venue":"Science","topic":"Genetic and Kidney Cyst Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":308,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; Canada Research Chairs; Canadian Institutes of Health Research; March of Dimes Foundation","keywords":"Cerebrospinal fluid; Zebrafish; Spinal Curvatures; Motile cilium; Cilium; Scoliosis; Idiopathic scoliosis; Anatomy; Curvature; Fish <Actinopterygii>; Mechanism (biology); SPINE (molecular biology); Fluid dynamics; Medicine; Biology; Neuroscience; Mechanics; Cell biology; Physics; Surgery; Geometry; Mathematics; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002037455,0.0006821875,0.0003251797,0.001070753,0.0004783139,0.000329402,0.0004204129,0.0008935712,0.003919933],"category_scores_gemma":[0.0002505503,0.0003340406,0.0004748093,0.0002118345,0.001098157,0.0003329863,0.0006367086,0.0009952926,0.0005459582],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006595452,"about_ca_system_score_gemma":0.0006604714,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004658348,"about_ca_topic_score_gemma":0.01002447,"domain_scores_codex":[0.999739,0.00003004951,0.0000234499,0.00005613077,0.0001140982,0.00003729824],"domain_scores_gemma":[0.9997255,0.0000399766,0.0001323283,0.00001897785,0.00002739516,0.0000558105],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00006266929,0.00002136245,0.0006193779,0.00008283462,0.00001464724,0.0004578309,0.00004313207,0.0002102213,0.9957586,0.0005914836,0.0002508927,0.001886919],"study_design_scores_gemma":[0.00007916235,0.0005206381,0.02197466,0.0000945808,0.0001148302,0.004379553,0.0001593956,0.003436246,0.9596714,0.0007461525,0.008782489,0.00004081894],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9594459,0.002970498,0.02760598,0.001126397,0.0001600194,0.0001707841,0.001837869,0.0007941778,0.00588833],"genre_scores_gemma":[0.9790607,0.002466661,0.009669319,0.0001972332,0.00001492083,0.0001103569,0.0008100462,0.0001291697,0.007541494],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004658348,"threshold_uncertainty_score":0.0131135,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00880477874276999,"score_gpt":0.2393109660282522,"score_spread":0.2305061872854822,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}