{"id":"W2416409425","doi":"10.1158/1538-7445.am2015-4271","title":"Abstract 4271: Lack of CD47 membrane mobility contributes to the poor erythrocyte binding of SIRPαFc, a novel CD47-blocking cancer immunotherapeutic","year":2015,"lang":"en","type":"article","venue":"Cancer Research","topic":"Erythrocyte Function and Pathophysiology","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Trillium Therapeutics (Canada)","funders":"","keywords":"CD47; Antibody; Biology; Plasma protein binding; Phagocytosis; Cell biology; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001762573,0.0001807723,0.0002286612,0.0001244951,0.0001371885,0.0002570662,0.0001226774,0.0003290238,0.003156782],"category_scores_gemma":[0.0001663505,0.0000947739,0.0001641632,0.0001154239,0.0001676635,0.00009307162,0.0001430723,0.0003594619,0.0006663218],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001438546,"about_ca_system_score_gemma":0.0001135934,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007774805,"about_ca_topic_score_gemma":0.0003217379,"domain_scores_codex":[0.9998536,0.00003976687,0.000009508753,0.0000242714,0.00003737747,0.00003534498],"domain_scores_gemma":[0.9999056,0.00002309407,0.00001782972,0.00001453012,0.00001096368,0.00002791162],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002062601,0.00003117057,0.0005543842,0.00002295729,0.000005986873,0.0001489632,0.00001738842,0.00002990663,0.9970247,0.00008542858,0.0001539035,0.001718948],"study_design_scores_gemma":[0.00002191476,0.0005407897,0.01936289,0.00000718383,0.00002369485,0.002522156,0.00004089542,0.001213146,0.9710056,0.00006605346,0.005190421,0.000005163134],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938547,0.002027644,0.002057997,0.0001862386,0.0000259981,0.00002301393,0.0001897632,0.00003750565,0.00159718],"genre_scores_gemma":[0.9970357,0.0003733877,0.0004222652,0.00007384353,0.000008147315,0.00001160729,0.0002963439,0.00001516561,0.001763432],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003156782,"threshold_uncertainty_score":0.01056051,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2709087422683971,"score_gpt":0.4587590791183107,"score_spread":0.1878503368499136,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}