{"id":"W2416468153","doi":"10.1128/aac.01139-15","title":"3-Halo Chloroquine Derivatives Overcome Plasmodium falciparum Chloroquine Resistance Transporter-Mediated Drug Resistance in P. falciparum","year":2015,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Malaria Research and Control","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Plasmodium falciparum; Chloroquine; Drug resistance; Pharmacology; Drug; Virology; Transporter; Malaria; Biology; Medicine; Microbiology; Immunology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001007905,0.0002224053,0.0003159115,0.0001091906,0.0001052279,0.0001424317,0.0001826436,0.0001507684,0.0007348053],"category_scores_gemma":[0.000137243,0.0001100803,0.0001666024,0.00009056614,0.0001902371,0.0001328154,0.0001107283,0.0004287226,0.000122391],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000126195,"about_ca_system_score_gemma":0.0001757451,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00105225,"about_ca_topic_score_gemma":0.003064617,"domain_scores_codex":[0.9999325,0.00001581931,0.000005815083,0.000007919909,0.00001943433,0.00001839903],"domain_scores_gemma":[0.9999106,0.00002389109,0.00001871266,0.00001019836,0.0000146021,0.000021921],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000300662,0.00007056298,0.0002858611,0.00006988324,0.000008136614,0.00006679291,0.00002819924,0.0001307268,0.9964595,0.00004681472,0.00004877915,0.002484041],"study_design_scores_gemma":[0.0001028893,0.003443922,0.007949747,0.00001015042,0.00003726241,0.0004211143,0.00003738764,0.0006212784,0.9847308,0.00002845918,0.002606573,0.00001051468],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973833,0.001225925,0.0003951413,0.00004229235,0.0000111863,0.00002967522,0.00008767417,0.00002578252,0.0007989843],"genre_scores_gemma":[0.9977571,0.0008427813,0.0006571588,0.00003647053,0.000008412551,0.00001061101,0.0001273279,0.000007646431,0.0005523814],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00105225,"threshold_uncertainty_score":0.002458155,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02121587956475537,"score_gpt":0.2716930608527903,"score_spread":0.250477181288035,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}