{"id":"W2416592645","doi":"10.3990/1.9789036540865","title":"The many faces of alpha synuclein: from phospholipid bilayer interactions to amyloid aggregation","year":2016,"lang":"en","type":"dissertation","venue":"","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of Twente; Vrije Universiteit Amsterdam; Universität Konstanz; University of Alberta","keywords":"Membrane; Biophysics; Phospholipid; Chemistry; Fluorescence recovery after photobleaching; Amyloid (mycology); Lipid bilayer; Fluorescence correlation spectroscopy; Biological membrane; Alpha-synuclein; Biochemistry; Biology; Molecule; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005158296,0.0003866048,0.0004425101,0.0003705409,0.0007664541,0.002281358,0.0004316175,0.001257198,0.001142243],"category_scores_gemma":[0.0007033659,0.0004198468,0.0003101785,0.000402457,0.00157885,0.003775083,0.001314306,0.00212251,0.0009294805],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005584185,"about_ca_system_score_gemma":0.000467912,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003393831,"about_ca_topic_score_gemma":0.0003832706,"domain_scores_codex":[0.9997095,0.00005644136,0.00001267342,0.0000576457,0.0001199856,0.000043726],"domain_scores_gemma":[0.9997817,0.00007041281,0.00004174695,0.00001600499,0.00006277193,0.00002739085],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003611769,0.000107374,0.002769107,0.004028789,0.00009660904,0.003752993,0.005353559,0.003327392,0.6339295,0.1559859,0.009622108,0.1806657],"study_design_scores_gemma":[0.00005638815,0.000628118,0.009360717,0.001976245,0.000144591,0.005930563,0.01006024,0.01054003,0.4117177,0.2801098,0.2691423,0.0003334103],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.3168054,0.5290871,0.04573558,0.06834479,0.002989177,0.000089727,0.0002795866,0.0003392484,0.03632936],"genre_scores_gemma":[0.6163984,0.3504997,0.009937814,0.003989535,0.001043332,0.0000826161,0.0001173395,0.00006516986,0.01786613],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.002281358,"threshold_uncertainty_score":0.004051626,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02061190173142199,"score_gpt":0.3353947852442022,"score_spread":0.3147828835127803,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}