{"id":"W2416659570","doi":"10.1038/mto.2015.14","title":"Chimeric antigen receptor–engineered T cells as oncolytic virus carriers","year":2015,"lang":"en","type":"article","venue":"Molecular Therapy — Oncolytics","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; McMaster University Medical Centre","funders":"","keywords":"Oncolytic virus; Chimeric antigen receptor; Adoptive cell transfer; Virus; Immune system; Antigen; Cancer research; Antibody; Immunology; Receptor; Biology; Immunotherapy; Virology; T cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002859091,0.0003909108,0.000248151,0.000286818,0.00007966746,0.0004201084,0.0003822771,0.0006038647,0.0006906511],"category_scores_gemma":[0.0002029738,0.0001879022,0.0003196577,0.0001869591,0.0002442019,0.0003717014,0.0002632245,0.0007021754,0.0005016566],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002459768,"about_ca_system_score_gemma":0.0002120456,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003542875,"about_ca_topic_score_gemma":0.0002760718,"domain_scores_codex":[0.9997265,0.00009171537,0.00001646155,0.00004128443,0.00006597347,0.00005808706],"domain_scores_gemma":[0.9999259,0.00001855514,0.00002216523,0.00001022299,0.00001105968,0.00001206479],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001373792,0.00006272864,0.00008670401,0.0001042355,0.00001581053,0.00007694189,0.00002851178,0.001030284,0.989753,0.001108649,0.000235105,0.007360678],"study_design_scores_gemma":[0.0001118031,0.001225599,0.0003295152,0.00002068754,0.00005045249,0.0005400975,0.00001777106,0.007187584,0.9746255,0.0003626863,0.01551337,0.00001500703],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8541168,0.02135959,0.1156431,0.0004346436,0.0003725624,0.0005396217,0.0004143371,0.000635131,0.006484202],"genre_scores_gemma":[0.9651944,0.004452674,0.02671168,0.0001259977,0.00003859122,0.0001796111,0.000282576,0.00005346182,0.00296102],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006906511,"threshold_uncertainty_score":0.002310395,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03594522134011999,"score_gpt":0.3239435815978033,"score_spread":0.2879983602576833,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}