{"id":"W2416666529","doi":"10.1172/jci83005","title":"Metabolic regulation of immune responses: therapeutic opportunities","year":2016,"lang":"en","type":"review","venue":"Journal of Clinical Investigation","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":97,"is_retracted":false,"has_abstract":true,"ca_institutions":"Trinity College","funders":"Trinity College Dublin; Science Foundation Ireland","keywords":"Immune system; Biology; Cell metabolism; Metabolic pathway; Cell biology; Signal transduction; Immunity; Metabolism; Cellular metabolism; Cell; Metabolic control analysis; T cell; Immunology; Biochemistry; Biotechnology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000537059,0.000668755,0.001154162,0.001485638,0.0002638134,0.001037037,0.0007024254,0.001384046,0.003612694],"category_scores_gemma":[0.0005354413,0.000182186,0.0004529339,0.0009234714,0.0004912965,0.00129994,0.0007454022,0.002196288,0.001591366],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000501685,"about_ca_system_score_gemma":0.0006867327,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003396122,"about_ca_topic_score_gemma":0.0008340846,"domain_scores_codex":[0.9998497,0.00003453641,0.00001835527,0.00002462079,0.00005096806,0.00002181211],"domain_scores_gemma":[0.9997967,0.00008962288,0.00002494728,0.000008106283,0.0000517717,0.00002895454],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001200956,0.0001356191,0.0001728434,0.008709581,0.00005515194,0.0004042341,0.00007429434,0.0003286903,0.004006598,0.007826166,0.02480491,0.9533619],"study_design_scores_gemma":[0.0000244608,0.0001673778,0.0005799006,0.002721667,0.00006339321,0.002271488,0.00007363721,0.000133934,0.0009303738,0.00419201,0.9888222,0.00001944184],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001642135,0.9977392,0.0002038363,0.0005500262,0.0003441955,0.000004186732,0.000009260693,0.00000870791,0.0009763232],"genre_scores_gemma":[0.001467769,0.9967134,0.0003125445,0.0003258931,0.0004219671,0.000008736768,0.00002157789,0.000002123885,0.0007259175],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003612694,"threshold_uncertainty_score":0.01208568,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2677842433515641,"score_gpt":0.422442079984779,"score_spread":0.1546578366332148,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}