{"id":"W2416666529","doi":"10.1172/jci83005","title":"Metabolic regulation of immune responses: therapeutic opportunities","year":2016,"lang":"en","type":"review","venue":"Journal of Clinical Investigation","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":97,"is_retracted":false,"has_abstract":true,"ca_institutions":"Trinity College","funders":"Trinity College Dublin; Science Foundation Ireland","keywords":"Immune system; Biology; Cell metabolism; Metabolic pathway; Cell biology; Signal transduction; Immunity; Metabolism; Cellular metabolism; Cell; Metabolic control analysis; T cell; Immunology; Biochemistry; Biotechnology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.003830627,0.0002660273,0.002291655,0.0004928973,0.00006779543,0.0000155717,0.0002852024,0.0008034452,0.001026373],"category_scores_gemma":[0.00193089,0.0001671361,0.001402314,0.0001600461,0.0004695241,0.0003516675,0.00003806392,0.0008684971,0.0001913545],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004047459,"about_ca_system_score_gemma":0.0008411111,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004987088,"about_ca_topic_score_gemma":2.636107e-7,"domain_scores_codex":[0.9919209,0.002811112,0.004828813,0.000173879,0.0001095125,0.0001557214],"domain_scores_gemma":[0.9892066,0.002184898,0.007622594,0.0003293679,0.0006123382,0.00004420055],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000295931,0.00007960095,0.0000172515,0.0006335872,0.0009902512,0.00000140166,0.00004721872,2.02516e-7,0.002273399,0.001743157,0.003352239,0.9905658],"study_design_scores_gemma":[0.0006796445,0.000431363,0.0004448211,0.007679001,0.00107793,0.000181243,0.00004728448,4.518408e-7,0.00125949,0.0006462386,0.9873974,0.0001551326],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003106346,0.9902763,0.0002010754,0.0002067017,0.008381237,0.0002140273,0.000007917101,0.00001397565,0.0003881388],"genre_scores_gemma":[0.0007287186,0.9871493,0.00006223658,0.000101216,0.000327987,0.000005722198,0.0000746638,0.00003013892,0.01152002],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9904106,"threshold_uncertainty_score":0.9998868,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2677842433515641,"score_gpt":0.422442079984779,"score_spread":0.1546578366332148,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}