{"id":"W2417253274","doi":"10.1083/jcb.201511053","title":"T cell activation requires force generation","year":2016,"lang":"en","type":"article","venue":"The Journal of Cell Biology","topic":"Force Microscopy Techniques and Applications","field":"Physics and Astronomy","cited_by":200,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Division of Chemical, Bioengineering, Environmental, and Transport Systems; National Institute of General Medical Sciences; Children's Health Research Institute; National Institutes of Health; National Science Foundation","keywords":"T-cell receptor; Stimulation; Cytoskeleton; Atomic force microscopy; Cantilever; Actin; Biophysics; T cell; Antigen; Microscopy; Chemistry; Actin cytoskeleton; Immunological synapse; Cell biology; Receptor; Cell; Materials science; Nanotechnology; Biology; Physics; Immunology; Biochemistry; Immune system; Neuroscience; Optics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000174112,0.00005158499,0.00007214474,0.00002366761,0.00006928745,0.000005974065,0.0001398151,0.00002600689,0.0001720127],"category_scores_gemma":[0.00000176086,0.00002419776,0.00004501995,0.00003662803,0.00004389336,0.00006239346,0.0000178641,0.00005966043,0.00001334448],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001396949,"about_ca_system_score_gemma":0.00002528078,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001390536,"about_ca_topic_score_gemma":2.425445e-7,"domain_scores_codex":[0.999619,0.00004541394,0.0001789084,0.0000425021,0.0000291175,0.00008502456],"domain_scores_gemma":[0.999486,0.00005937138,0.0002597174,0.0001060055,0.00006985202,0.00001903402],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00000873111,0.00001860719,0.0001224564,6.442364e-7,0.000004177675,1.353946e-8,0.00003467301,0.000006916188,0.9893082,0.004279358,0.002088112,0.004128099],"study_design_scores_gemma":[0.0001589505,0.00009595745,0.0000360875,0.000004966282,0.00001048009,6.819667e-7,0.00002721945,0.00002957681,0.975343,0.007832378,0.01642434,0.00003638635],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7291568,0.00003203656,0.2645974,0.0006121296,0.00004888236,0.00006074447,0.00000472299,0.000004785071,0.005482488],"genre_scores_gemma":[0.9972729,0.00003230452,0.001070891,0.00005692017,0.0003629934,0.000002662197,0.000003000651,0.000005077361,0.001193266],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2681161,"threshold_uncertainty_score":0.1883418,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01343095684487759,"score_gpt":0.2702339618128941,"score_spread":0.2568030049680164,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}