{"id":"W2417253274","doi":"10.1083/jcb.201511053","title":"T cell activation requires force generation","year":2016,"lang":"en","type":"article","venue":"The Journal of Cell Biology","topic":"Force Microscopy Techniques and Applications","field":"Physics and Astronomy","cited_by":200,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Division of Chemical, Bioengineering, Environmental, and Transport Systems; National Institute of General Medical Sciences; Children's Health Research Institute; National Institutes of Health; National Science Foundation","keywords":"T-cell receptor; Stimulation; Cytoskeleton; Atomic force microscopy; Cantilever; Actin; Biophysics; T cell; Antigen; Microscopy; Chemistry; Actin cytoskeleton; Immunological synapse; Cell biology; Receptor; Cell; Materials science; Nanotechnology; Biology; Physics; Immunology; Biochemistry; Immune system; Neuroscience; Optics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001304283,0.0002373178,0.0001907824,0.0001810074,0.0002657517,0.0004348305,0.0001960803,0.0005768479,0.001390053],"category_scores_gemma":[0.000311363,0.0001673549,0.0001788493,0.0001614162,0.0003096024,0.0003309888,0.000310025,0.0005147345,0.000421978],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002770279,"about_ca_system_score_gemma":0.0001806663,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003021977,"about_ca_topic_score_gemma":0.0002440547,"domain_scores_codex":[0.9998034,0.00001890402,0.000009876035,0.00004978764,0.00007765111,0.00004039234],"domain_scores_gemma":[0.9998909,0.00004272303,0.00001890584,0.00001184318,0.00001999888,0.00001547594],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002009565,0.000005852404,0.00007895691,0.00002390078,0.000001594213,0.0000392518,0.000009844134,0.00009523449,0.9960448,0.0003862795,0.00008182416,0.003212548],"study_design_scores_gemma":[0.00002830482,0.0001330796,0.003140423,0.0000116092,0.000008531787,0.0005808605,0.00002716197,0.005435279,0.983187,0.001089951,0.006341934,0.00001594396],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9185314,0.005190909,0.06422419,0.00101598,0.0003385629,0.00008732722,0.0002967553,0.0005259804,0.009788956],"genre_scores_gemma":[0.9849556,0.001132055,0.01153927,0.0001914033,0.00007792486,0.00006091037,0.00009183167,0.00002567827,0.001925278],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001390053,"threshold_uncertainty_score":0.004650176,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01343095684487759,"score_gpt":0.2702339618128941,"score_spread":0.2568030049680164,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}