{"id":"W2417443854","doi":"10.1038/srep13688","title":"Compensatory T-type Ca2+ channel activity alters D2-autoreceptor responses of Substantia nigra dopamine neurons from Cav1.3 L-type Ca2+ channel KO mice","year":2015,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; Michael Smith Health Research BC; University of British Columbia","funders":"Canadian Institutes of Health Research; Austrian Science Fund; Bundesministerium für Bildung und Forschung; Universität Ulm; Deutsche Forschungsgemeinschaft","keywords":"Substantia nigra; Autoreceptor; Voltage-dependent calcium channel; Calcium channel; Dopamine; T-type calcium channel; L-type calcium channel; P-type calcium channel; Cav1.2; Electrophysiology; Mibefradil; Neuroscience; Bursting; Internal medicine; Endocrinology; Biology; Chemistry; Calcium; Medicine; Dopaminergic; Receptor; Agonist","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002547566,0.0007635477,0.0006702978,0.0007661515,0.00031486,0.0006723503,0.0005532788,0.001105889,0.003454567],"category_scores_gemma":[0.0002816519,0.0004656219,0.0008521402,0.0002462695,0.0008616438,0.0005054857,0.0003989483,0.002042522,0.0008003909],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005951909,"about_ca_system_score_gemma":0.0003437582,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00167662,"about_ca_topic_score_gemma":0.002826375,"domain_scores_codex":[0.9995416,0.00003266129,0.00008290339,0.0001668775,0.00008582387,0.00009006968],"domain_scores_gemma":[0.9994265,0.00006465378,0.0002151305,0.00003902342,0.00004209586,0.0002126259],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002074291,0.00003240334,0.0001868951,0.00002846019,0.000007911292,0.0001302982,0.00004370987,0.00003440286,0.9988092,0.00008449228,0.00003889568,0.0003959819],"study_design_scores_gemma":[0.0001464271,0.0007273054,0.02220603,0.00004179243,0.0001340692,0.001568302,0.0002580523,0.001901233,0.9692784,0.0003206184,0.003371899,0.0000459445],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927109,0.0005541899,0.003293944,0.0002229777,0.00005829187,0.00003761586,0.002069143,0.0002229698,0.0008299616],"genre_scores_gemma":[0.9868098,0.0008778587,0.003409427,0.0002134029,0.00002809073,0.0002136642,0.001813144,0.0004177534,0.00621677],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003454567,"threshold_uncertainty_score":0.01155668,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03404350379416734,"score_gpt":0.2651940234019937,"score_spread":0.2311505196078263,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}