{"id":"W2417500499","doi":"10.1007/978-1-61779-337-0_7","title":"Kinase Inhibitor Selectivity Profiling Using Differential Scanning Fluorimetry","year":2011,"lang":"en","type":"article","venue":"Methods in molecular biology","topic":"Enzyme Structure and Function","field":"Materials Science","cited_by":178,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; Wellcome Trust","keywords":"Enzyme; Chemistry; Virtual screening; Drug discovery; Kinase; Combinatorial chemistry; Computational biology; Target protein; Ligand binding assay; Selectivity; Substrate (aquarium); Fluorescence spectroscopy; Biochemistry; Fluorescence; Biophysics; Biology; Receptor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008938906,0.0007203007,0.0007075159,0.001006617,0.0003236447,0.0005341364,0.0006082577,0.0004645528,0.001124483],"category_scores_gemma":[0.0007504699,0.0003515872,0.0004981526,0.0008462394,0.0003693344,0.0003759235,0.0003687413,0.00104358,0.0005233375],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001101009,"about_ca_system_score_gemma":0.0003353249,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008089974,"about_ca_topic_score_gemma":0.001299673,"domain_scores_codex":[0.9991085,0.0001233853,0.00004775982,0.0002004789,0.0004101261,0.0001098305],"domain_scores_gemma":[0.9995362,0.000185178,0.00008039766,0.00004915599,0.0001297015,0.00001929369],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007824033,0.00002861447,0.0002888267,0.00008744193,0.00001265988,0.00002078115,0.00003079396,0.0008207085,0.9863115,0.0003018345,0.0003765098,0.01164203],"study_design_scores_gemma":[0.000003983265,0.00005941472,0.0003984499,0.000002569161,0.000008197359,0.00002816213,0.000005167229,0.002858463,0.9954119,0.00005046387,0.001164797,0.000008387879],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.7288373,0.006772218,0.2487395,0.0004932313,0.000192394,0.0003065435,0.002441606,0.002477414,0.009739882],"genre_scores_gemma":[0.8595081,0.007711416,0.123022,0.0002132429,0.0000475484,0.0004651346,0.001708613,0.0001511281,0.007172919],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.001124483,"threshold_uncertainty_score":0.007988393,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04390471654794068,"score_gpt":0.368986993629731,"score_spread":0.3250822770817903,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}