{"id":"W2417564225","doi":"10.1016/j.bbadis.2016.06.007","title":"Metabolic signatures of Huntington's disease (HD): 1 H NMR analysis of the polar metabolome in post-mortem human brain","year":2016,"lang":"en","type":"article","venue":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":51,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Queen's University; Medical Research Council; Alzheimer's Society","keywords":"Striatum; Metabolite; Huntington's disease; Frontal lobe; Pathophysiology; Internal medicine; Endocrinology; Huntingtin; Biology; Chemistry; Neuroscience; Medicine; Dopamine; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002726687,0.0005762985,0.001066802,0.0009167145,0.0001151527,0.00003797638,0.001561771,0.00009078211,0.00007000451],"category_scores_gemma":[0.002558796,0.0003982619,0.001591414,0.002701409,0.0009336532,0.0002170515,0.0005467041,0.0001796098,0.000003359952],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002582752,"about_ca_system_score_gemma":0.0004720623,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000853373,"about_ca_topic_score_gemma":0.00002148262,"domain_scores_codex":[0.9945144,0.001502172,0.0009963909,0.001179816,0.001248945,0.0005582515],"domain_scores_gemma":[0.9957931,0.0004172597,0.0009995371,0.001989143,0.0002872219,0.0005137142],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003700148,0.001350745,0.001517748,0.0001082575,0.0004497937,0.0000066398,0.00008333526,0.0001702721,0.9927689,0.003032887,0.00004711638,0.00009432823],"study_design_scores_gemma":[0.0005222138,0.00005392388,0.3816157,0.00005622331,0.001802762,3.700855e-8,0.00001360316,0.00003146086,0.6153193,0.0003134501,0.00000933424,0.0002620284],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913999,0.0004068726,0.00002344012,0.00368848,0.00006640184,0.0007212967,0.003620724,0.00003711047,0.00003579706],"genre_scores_gemma":[0.9982257,0.0000820436,0.00006494779,0.001370218,0.00002879965,0.00006035614,0.00005396526,0.00007692436,0.00003699869],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.380098,"threshold_uncertainty_score":0.9998469,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01098296471957907,"score_gpt":0.2596626890701388,"score_spread":0.2486797243505597,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}