{"id":"W2417576966","doi":"10.1152/jappl.2001.90.1.358","title":"Invited Review: Molecular mechanisms of phenotypic plasticity in smooth muscle cells","year":2001,"lang":"en","type":"review","venue":"Journal of Applied Physiology","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":254,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"National Heart, Lung, and Blood Institute","keywords":"RHOA; Biology; Phenotype; Cell biology; Serum response factor; GTPase; Small GTPase; Cytoskeleton; Gene isoform; Signal transduction; Transcription factor; Actin; Phenotypic plasticity; Regulation of gene expression; Gene expression; Actin cytoskeleton; Gene; Cell; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003240268,0.0003460089,0.001741413,0.0002171709,0.00001996469,0.000004213708,0.0003761029,0.0004430704,0.00004058316],"category_scores_gemma":[0.00005214764,0.0002853904,0.0005168996,0.0003335161,0.00007826629,0.000002754962,0.0001176876,0.0003961503,0.000004199509],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000367789,"about_ca_system_score_gemma":0.0001600651,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002138594,"about_ca_topic_score_gemma":0.00000103643,"domain_scores_codex":[0.9978249,0.0001889676,0.001228548,0.0003117403,0.0001888092,0.0002570109],"domain_scores_gemma":[0.9978262,0.00004044387,0.00162696,0.0002872692,0.0001278965,0.00009126431],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001037801,0.0002014234,3.265435e-8,0.01004231,0.0001620073,0.00002307768,0.000006064159,0.0002455567,0.8268761,0.0002891845,0.0006950266,0.1613554],"study_design_scores_gemma":[0.0007717462,0.0002853485,0.000009631016,0.01043642,0.0004967363,0.00002618169,0.000007156904,0.000009028109,0.0581914,0.001967135,0.9273638,0.0004354381],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001076827,0.9952784,0.002869851,0.00001934933,0.0001121221,0.0005196701,0.00001965164,0.000002965629,0.000101171],"genre_scores_gemma":[0.002371126,0.9956222,0.001149879,0.0005403204,0.0001623511,0.00002355162,0.00008408109,0.00004243158,0.000004099489],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9266688,"threshold_uncertainty_score":0.9999598,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01491103587532498,"score_gpt":0.2680400452928339,"score_spread":0.2531290094175089,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}