{"id":"W2417591912","doi":"10.1016/j.ejca.2016.05.014","title":"Rethinking end-points for bone-targeted therapy in advanced cancer","year":2016,"lang":"en","type":"article","venue":"European Journal of Cancer","topic":"Management of metastatic bone disease","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre; University of Ottawa; Ottawa Hospital","funders":"","keywords":"Medicine; Clinical trial; Oncology; Quality of life (healthcare); Targeted therapy; Placebo; Internal medicine; Cancer; Surgery; Pathology; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001363013,0.000150223,0.0003549261,0.0002020983,0.00002972789,0.00001389516,0.0001538941,0.00001440874,0.001166645],"category_scores_gemma":[0.0003010367,0.00009302612,0.0001632537,0.0001320359,0.00004576285,0.0001803369,0.00002433742,0.0001496734,0.000009350163],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001549137,"about_ca_system_score_gemma":0.000175066,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006984965,"about_ca_topic_score_gemma":0.00001505085,"domain_scores_codex":[0.9983449,0.0001971528,0.0006014354,0.000174645,0.0004195193,0.0002623497],"domain_scores_gemma":[0.9987831,0.00009438831,0.0004764757,0.0001933882,0.0002866455,0.0001660698],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.004433556,0.0001593813,0.01600079,0.0001110889,0.00028672,0.0006091128,0.001091066,0.00003812677,0.02816282,0.0001036821,0.00980428,0.9391994],"study_design_scores_gemma":[0.05450982,0.002123784,0.4366456,0.005366927,0.0004137944,0.00004622935,0.0002886032,0.00008386403,0.01379855,0.00177099,0.4843784,0.0005734132],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9537507,0.01425626,0.00300714,0.02391993,0.001075675,0.0006698166,0.00003808825,0.00002743553,0.003254966],"genre_scores_gemma":[0.9848889,0.00466625,0.004578129,0.002934059,0.0004664501,0.00001937531,0.000001335598,0.00006627552,0.002379213],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.938626,"threshold_uncertainty_score":0.9997464,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03743068080916606,"score_gpt":0.3290557361748553,"score_spread":0.2916250553656893,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}