{"id":"W2417921410","doi":"10.1385/1-59259-087-x:305","title":"Radioligand Binding Assay","year":2003,"lang":"en","type":"article","venue":"Humana Press eBooks","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute","funders":"Medical Research Council; Merck Canada","keywords":"Radioligand; Radioligand Assay; Receptor; Ligand binding assay; Agonist; Chemistry; Ligand (biochemistry); Biophysics; Centrifugation; Receptor–ligand kinetics; Dissociation constant; Molecular biology; Chromatography; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002467383,0.0001192133,0.0001029476,0.00002411318,0.0001166163,0.00004186537,0.0001195419,0.0001023948,0.00006648819],"category_scores_gemma":[0.00003156997,0.0001127141,0.00006997558,0.000006729978,0.00002846695,0.000001441227,0.00003370926,0.0000662722,0.000006489848],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006293066,"about_ca_system_score_gemma":0.0000192018,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000114148,"about_ca_topic_score_gemma":0.000004198654,"domain_scores_codex":[0.9992349,0.00007410055,0.0001300099,0.0002490267,0.00009330894,0.0002186795],"domain_scores_gemma":[0.9996122,0.000006446376,0.00004727463,0.0002398914,0.00002696994,0.00006725085],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001022567,0.000011711,0.00001271396,0.00001136369,0.00004725299,0.000004551154,0.00007499487,0.0000212294,0.9713982,0.02182569,0.001883365,0.004698733],"study_design_scores_gemma":[0.0002052377,0.00004355294,0.000002675449,0.000006640657,0.00000869332,0.000007410456,0.00001709866,0.000009609943,0.6941642,0.0001819706,0.3052339,0.0001190125],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6267698,0.006185635,0.01214228,0.000005015449,0.000701714,0.0003500057,0.00001040466,0.00005401787,0.3537811],"genre_scores_gemma":[0.9860406,0.0001132696,0.0008544821,0.0000869408,0.000190048,0.00002168554,0.00001681461,0.00002905223,0.01264709],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3592708,"threshold_uncertainty_score":0.4596346,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03281169342689354,"score_gpt":0.254495778324852,"score_spread":0.2216840848979584,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}