{"id":"W2418010570","doi":"10.1038/cgt.2015.59","title":"Synergistic tumor suppression by adenovirus-mediated ING4/PTEN double gene therapy for gastric cancer","year":2015,"lang":"en","type":"article","venue":"Cancer Gene Therapy","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"Saskatchewan Cancer Agency","funders":"Government of Jiangsu Province; National Natural Science Foundation of China","keywords":"PTEN; Tensin; Cancer research; Downregulation and upregulation; Angiogenesis; Vascular endothelial growth factor; Tumor suppressor gene; Chemistry; Biology; Apoptosis; Cancer; Molecular biology; Carcinogenesis; PI3K/AKT/mTOR pathway; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000212061,0.000370542,0.0003118377,0.0003729995,0.0001486378,0.0002189292,0.0002557954,0.0002172685,0.001213071],"category_scores_gemma":[0.00007839451,0.0001502861,0.0003245249,0.0002553702,0.0003016614,0.0002591494,0.0002702498,0.0005417518,0.0001557449],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003075155,"about_ca_system_score_gemma":0.0003763956,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006584373,"about_ca_topic_score_gemma":0.0008815923,"domain_scores_codex":[0.999873,0.00002117671,0.000008707861,0.00002038958,0.00003654355,0.00004003981],"domain_scores_gemma":[0.9999697,0.000005215143,0.000007186972,0.000006139785,0.000002813892,0.000008966741],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004705701,0.0001277827,0.000244575,0.00006420234,0.00001591643,0.0000915551,0.00002480883,0.0004440002,0.9910795,0.0008829616,0.0001272171,0.0064269],"study_design_scores_gemma":[0.0001221138,0.0009290929,0.001214002,0.000004785566,0.00008436834,0.0003334577,0.00003758558,0.002550699,0.9905204,0.0002067231,0.003989142,0.000007706637],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9895083,0.001892259,0.005199885,0.0001772216,0.00007339849,0.0000495809,0.0001484033,0.0001344585,0.00281662],"genre_scores_gemma":[0.9959384,0.0006691099,0.001664239,0.00001934022,0.000007400743,0.00002814498,0.00007803042,0.00001018889,0.001585083],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001213071,"threshold_uncertainty_score":0.004058123,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03147214242679051,"score_gpt":0.2987137363986591,"score_spread":0.2672415939718685,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}