{"id":"W2418133124","doi":"10.2196/resprot.5535","title":"Determination of Anti-Adeno-Associated Viral Vector Neutralizing Antibodies in Patients With Heart Failure in the Cardiovascular Foundation of Colombia (ANVIAS): Study Protocol","year":2016,"lang":"en","type":"article","venue":"JMIR Research Protocols","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Clinical trial; Transduction (biophysics); Population; Adeno-associated virus; Serotype; Genetic enhancement; Heart failure; Immunology; Antibody; Virology; Vector (molecular biology); Internal medicine; Biology; Gene; Environmental health; Genetics","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001997816,0.001565342,0.001338733,0.001589326,0.002007045,0.001044591,0.001045641,0.0009418853,0.00828731],"category_scores_gemma":[0.001828396,0.0006356285,0.0007848869,0.0009911353,0.0006397362,0.000435352,0.00080534,0.000658834,0.001683385],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002794504,"about_ca_system_score_gemma":0.006279306,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01829522,"about_ca_topic_score_gemma":0.02783198,"domain_scores_codex":[0.9987448,0.0003975243,0.0002223875,0.0002707957,0.0001277738,0.0002366996],"domain_scores_gemma":[0.998519,0.0001099821,0.0003440571,0.0001180049,0.0006120176,0.000296975],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.02745948,0.01656196,0.813526,0.009825507,0.0005060181,0.003203838,0.00380906,0.001292912,0.007078676,0.00163071,0.03710586,0.07799993],"study_design_scores_gemma":[0.00522158,0.01213346,0.9275554,0.002011446,0.0003183113,0.001378616,0.003378439,0.0008580058,0.001112139,0.0003511524,0.04553845,0.0001428892],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.3846204,0.003534881,0.005429667,0.0009988935,0.0003733194,0.5472831,0.03733804,0.0001618911,0.0202599],"genre_scores_gemma":[0.3570924,0.00250111,0.01238078,0.001254707,0.0002360866,0.603153,0.01832822,0.00002713947,0.005026572],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.01829522,"threshold_uncertainty_score":0.03637749,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05885588465211883,"score_gpt":0.4360677304296388,"score_spread":0.37721184577752,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}