{"id":"W2418155401","doi":"10.1136/bmj.i859","title":"New and emerging targeted therapies for cystic fibrosis","year":2016,"lang":"en","type":"review","venue":"BMJ","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":146,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Diabetes and Digestive and Kidney Diseases","keywords":"Ivacaftor; Cystic fibrosis; Cystic fibrosis transmembrane conductance regulator; Medicine; Genetic enhancement; Disease; Bioinformatics; Loss function; Gene; Computational biology; Biology; Pathology; Genetics; Phenotype; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006717514,0.0006761779,0.001147367,0.002310349,0.0002962013,0.0007469018,0.0007033501,0.001282707,0.006465839],"category_scores_gemma":[0.0009569661,0.0001999067,0.0007630337,0.001301821,0.0004319225,0.001269944,0.0007673549,0.002474305,0.002572234],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005829989,"about_ca_system_score_gemma":0.0008873368,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007959202,"about_ca_topic_score_gemma":0.0020241,"domain_scores_codex":[0.9996905,0.0000497211,0.0000389123,0.00003856583,0.0001506306,0.00003156423],"domain_scores_gemma":[0.9996616,0.000171684,0.0000393751,0.000009396731,0.00008476082,0.00003331186],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000790372,0.00008674878,0.0001314805,0.01825177,0.00008997386,0.0002932164,0.00008239475,0.0002191054,0.002218152,0.004700977,0.04204927,0.9317977],"study_design_scores_gemma":[0.00002932029,0.00009442076,0.0005030988,0.00381436,0.00008980757,0.001171085,0.00005294646,0.00005920771,0.0003380215,0.00199395,0.9918398,0.0000139963],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00009571508,0.9982035,0.00009660203,0.0004169675,0.0002600183,0.000005200036,0.00001805699,0.000008733707,0.0008952011],"genre_scores_gemma":[0.0005280326,0.9982063,0.0001821984,0.0003088445,0.000190883,0.000006631605,0.00002880303,0.000001579374,0.0005467171],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.006465839,"threshold_uncertainty_score":0.02163041,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04434192006485149,"score_gpt":0.4055528411478235,"score_spread":0.361210921082972,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}