{"id":"W2418163513","doi":"10.1038/srep22066","title":"Pygo2 functions as a prognostic factor for glioma due to its up-regulation of H3K4me3 and promotion of MLL1/MLL2 complex recruitment","year":2016,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Hubei University; Hubei University of Technology","keywords":"Wnt signaling pathway; H3K4me3; Biology; Cancer research; Glioma; Histone; Epigenetics; Bioinformatics; Signal transduction; Cell biology; Genetics; Promoter; Gene expression; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009737245,0.0002689935,0.0001585518,0.0004421078,0.0001745753,0.0002085484,0.0001060819,0.0001400289,0.00122199],"category_scores_gemma":[0.0001508489,0.00009887854,0.000158477,0.0002777599,0.0002288472,0.0001603053,0.0003073836,0.0002344065,0.0001997657],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001884469,"about_ca_system_score_gemma":0.0001386043,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006068685,"about_ca_topic_score_gemma":0.0008258518,"domain_scores_codex":[0.9999312,0.00001043058,0.000003218426,0.00001665929,0.00002063136,0.0000179028],"domain_scores_gemma":[0.9999424,0.000005692999,0.00001997523,0.000005658045,0.00000688008,0.00001922806],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003358216,0.00001090206,0.009904088,0.00005080448,0.00001659332,0.0002509117,0.00001959307,0.00008714385,0.9852475,0.00007494337,0.00006150919,0.003940226],"study_design_scores_gemma":[0.00003475423,0.0003051804,0.1810746,0.00001053672,0.00007351671,0.002079718,0.00007366585,0.002073914,0.8085923,0.0001827709,0.005486421,0.00001258896],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929052,0.003331042,0.002220234,0.00009578306,0.00001618709,0.00001231109,0.0002819291,0.00006032373,0.001077007],"genre_scores_gemma":[0.9977792,0.0004463574,0.0006160492,0.0000148399,0.000005806036,0.000005894764,0.0002653044,0.000004430416,0.0008620824],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00122199,"threshold_uncertainty_score":0.004087925,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05325443306973943,"score_gpt":0.3042739839795442,"score_spread":0.2510195509098048,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}